Source: Annual Congress 2002 - Aspects of respiratory disease in primary care
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Methacholine challenge test was estimated in 159 children (aged 5-15 years), among them 62 cases of moderate bronchial asthma, 62 children with mild asthma. Besides, persistent dry cough (duration over 6 months) without typical asthmatic attacks was the main symptom in 33 pediatric patients. Congenital anomalies and respiratory infections were excluded in all children. Control group consisted of 30 normal children without respiratory pathology and no atopic background. Methacholine test was positive in 100% of children with moderate asthma, in 84% of patients with mild asthma, and in 88% of children with cough variant of bronchial asthma. The same test was negative in every patient from the control group. Challenge methacholine dose (PD₂₀) was significantly lower in patients with moderate bronchial asthma (p<0,005), no reliable difference encountered in other groups. High and moderate degrees of bronchial hyperreactivity were revealed in 82% of patients with moderate asthma, in 50% with mild asthma, in 48% cases with cough variant. We conclude that our studies provide support to the fact of high sensitivity of methacholine test in investigation of respiratory allergy. In spite of the lack of typical asthma symptoms, the characteristics of airway responsiveness in pediatric patients with persistent cough and accompanying atopic manifestations are similar to those in typical mild cases of bronchial asthma. In half of such patients bronchial hyperreactivity approaches moderate and even high degrees.

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Citations should be made in the following way:
T. V. Kulichenko, O. F. Lukina, V. A. Revjakina (Moscow, Russia). Bronchial hyperreactivity in children with cough variant of bronchial asthma. Eur Respir J 2002; 20: Suppl. 38, 2985

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