Source: Annual Congress 2002 - Drug resistance in different areas
Disease area: Respiratory infections

Abstract

To invsetigate the trend of antituberculous drug resistance between 1990 and 2000, we conducted reviewing the records of tuberculous reference laboratory of the hospital by computer.
Lowenstein-Jensen culture media and indirect proportion method for susceptibility testing were used in this period.Drug resistance was classified as monoresistance (MR), compound resistance (CR) and multi-drug resistance (MDR).
Number of materials detected per year ranged between 17 186 and 23 685; % 1-2,4 (208-446/year) of them were resistant. In the resistant group, MR, CR and MDR ranged between %38,46, %11,5, %24,91 and %54,48, %33,33, %44,71, respectively.MR have been rising since 1994, whereas CR have been declining since 1995. Although MDR declined between 1992 and 1996, it's in rising trend since 1997.
The most common MR (%62)was against to streptomycien (S), sequentially %26,8 to rifampicin (R) and %18,3 to isoniaside (H).Mono ethambutol resistance was found in just only one material. Resistance to S and to H reached to peak levels in 1996 and 1993, respectively and then both declined. But, in 1997,H resistance began to rise again.In 1995, resistance to R reached to the peak level was % 33,33 and fluctuated during investigated period.
We concluded that these resistance ratios reflect antituberculous therapy applied in our country. Detected high S resistance and nonsignificant ethambutol (E) resistance provide superiority to E to be chosen as a fourth drug in treatment protocol. Rising in both MR and MDR indicate that national tuberculous control and therapy protocol is not enough as much as it's desired, yet.

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Citations should be made in the following way:
A. B. Dursun, Z. M. Guler, M. Atasever (Ankara, Turkey). Trends in antituberculous drug resistance pattern between 1990 and 2000 in a tuberculous reference hospital in Turkey. Eur Respir J 2002; 20: Suppl. 38, 2560

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