Source: Annual Congress 2002 - Drug resistance in different areas
Disease area: Respiratory infections

Abstract

Objective of this study was the investigation of homeostasis peculiarities among patients with pulmonary tuberculosis with different drug resistance genesis. Comparative blood lymphocytes drug sensibilization investigation in vitro among 54 patients excreting mono-resistant, polyresistant and MDR strains and among persons with kept anti-TB drugs sensibility was carried out. Fact was established that in vitro maximum lymphocytes sensitization to anti-TB drugs and CD4/CD8 indexes decreasing were marked in MDR-TB cases. Interesting parallel was observed: lymphocytes hypersensibilization to isoniazid and rifampicin among patients with MDR-TB along with resistance of M. tuberculosis identified in the same cases to isoniazid and rifampicin again. Reliable CD4 decrease and anti-TB IgG antibodies increase in ELIZA at the high dose resistance of M. tuberculosis to anti-TB drugs were observed in comparison with the same indexes among patients with low resistant M. tuberculosis. This data are of evidence of mutual influence of M. tuberculosis genome on the immune homeostasis among patients with MDR-TB under lasting coexistence conditions.

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A. H. Alenova, G. B. Rakishev, A. T. Ismailova, D. S. Dilmagambetov (Almaty, Kazakhstan). Macroorganism and microorganism mutual influence under MDR-TB conditions. Eur Respir J 2002; 20: Suppl. 38, 2558

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