Frequency of drug resistance and treatment results in patients with newly detected tuberculosis using standard chemotherapeutical regimen on the data of district hospital, Kiev
S. A. Cherenko, E. V. Ivankova ()
Source: Annual Congress 2002 - Drug resistance in different areas
Session: Drug resistance in different areas
Session type: Oral Presentation
Number: 2554
Disease area: Respiratory infections
Abstract We studied frequency and profile of drug resistance in new cases of pulmonary tuberculosis, detected in 1998 for one the biggest district of Kiev with population 200000. It were detected 101 patients that have never been treated with antituberculous drugs. Primary drug resistance was revealed in 27,7% patients (R - 7,9%, HS - 4,9%, H - 3,9%, S - 3,9%, RE -1,9%). Acquired drug resistance developed during standard WHO Category 1 chemotherapy in 4,9% patients (RS -1,9%, HR - 0,9%, R - 0,9%, S - 0,9%). Sputum conversion was achieved in 72,3% cases within 2,3 month: in 71,9% of patients with susceptible MBT and in 72,9% of patients with drug resistance (but not MDR). Conclusion: We revealed high level of drug resistance for newly detected pulmonary tuberculosis. Mono- and polyresistance (except of MDR) don't influence on treatment result in newly detected patients treated with standard chemotherapeutical regimen. The main reason of low treatment results were incompliance and treatment interruption.
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S. A. Cherenko, E. V. Ivankova (). Frequency of drug resistance and treatment results in patients with newly detected tuberculosis using standard chemotherapeutical regimen on the data of district hospital, Kiev. Eur Respir J 2002; 20: Suppl. 38, 2554
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