Source: Annual Congress 2002 - Miscellaneous respiratory infections in children
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Aim: To investigate nasal and lower airway nitric oxide (nNO and eNO respectively) in non-cystic fibrosis (CF) bronchiectasis (BE).
Methods: 29 children with BE diagnosed by chest CT scan were studied at a time of disease stability. All had CF excluded. If nNO was <250ppb, cilia beat frequency (CBF) and cilia structure were evaluated to exclude primary ciliary dyskinesia (PCD). Use of oral / inhaled steroids was documented. Spirometry and skin prick allergy tests to 4 common allergens were performed. ENO and nNO were measured by chemiluminescence using single breath and breath-holding techniques respectively. The results were compared with controls.
Results: There was no significant difference (P<0.05) in eNO and nNO levels between subjects with a presumed or an unknown cause for BE. There was no significant difference (P<0.05) in eNO and nNO levels in BE on or off steroids or when compared with control levels. Nine subjects fulfilled the NO criteria for PCD. Three had known immune deficiencies and normal CBF but only one had normal cilia structure confirmed. Six subjects had BE with no known cause, two of which had normal CBF and structure. The remaining 4 subjects had abnormal CBF but structural cilia studies had failed to establish a result.
Conclusion: Exhaled NO levels do have a role in monitoring corticosteroid therapy in children with non-CF BE. There may be a role for using NO for screening for PCD in children with bronchiectasis but more research is required.

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Citations should be made in the following way:
E. A. Edwards, C. Douglas, S. Broome, W. Ferguson, J. Kolbe, C. Byrnes (Auckland, New Zealand). Exhaled nitric oxide levels in children with non-cystic fibrosis bronchiectasis in New Zealand. Eur Respir J 2002; 20: Suppl. 38, 2106

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