Source: Annual Congress 2002 - Miscellaneous respiratory infections in children
Disease area: Paediatric lung diseases

Abstract

Introduction: Lipid peroxidation is a chain of catalytic processes by which unsaturated fatty acids react with free radicals, resulting in formation of hydrogen peroxide (H₂O₂). Constant hemoglobin auto-oxidation generates superoxide radicals (O2¿), which through spontaneous or enzymatic dismutation yield hydrogen peroxide. Infections and inflammations brings to the elevated local production of free radicals.
Objective of the study: To examine in vitro RBC liability to lipid peroxidation in anemias of chronic diseases in children compared to the changes in the activity of antioxidative enzymes, catalase (Ct), superoxide dismutase (SOD) and glutathione peroxidase (GPx).
Materials and methods: Antioxidative enzymes, catalase (Ct), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were examined in 6 patients with symptoms of mild anemia, recurrent respiratory infections and disregulation of the immune system, and 6 healthy children, as a control.
Results: There was reduction in GPx level, and catalase and SOD activities in the group with symptoms of mild anemia and recurrent respiratory infections (GPx/gHb:26.525±]1.87U/gHb; CAT/g%: 5.785±]2.51U/gHbx10⁴ ; SOD/gHb: 1004.56±]84.9 U/gHb) compared with the values of the control group (GPx/gHb: 34.675±]8.85U/gHb; CAT/g%: 12.275±]2.91 U/gHbx10⁴; SOD activities/gHb: 1040.025 ±]76.28 U/gHb).
It may be concluded that red blood cells liability to lipid peroxidation is increased in the states of recurrent respiratory infections and chronic activation of immune system compared to the control group.

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T. V. Zaharov, S. S. Pljaskic-Kamenov, G. D. Kostic, V. B. Djordjevic, B. A. Kamenov (Pirot, Nis, Yugoslavia). Red cell lipid peroxidation and antioxidant enzymes in anemia in children with respiratory infections. Eur Respir J 2002; 20: Suppl. 38, 2093

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