ICAM-1 is shed as dimers by a regulated mechanism from cells in the inflamed pleural space and is biologically active

M. R. Melis, E. Pace, M. Profita, M. Spatafora, M. Ferraro, A. Tipa, A. M. Vignola, C. H. Mody, G. Bonsignore, M. Gjomarkaj (Palermo, Italy; Calgary, Canada)

Source: Annual Congress 2002 - Biology of immune recognition
Session: Biology of immune recognition
Session type: Oral Presentation
Number: 1415
Disease area: Respiratory infections, Thoracic oncology

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. R. Melis, E. Pace, M. Profita, M. Spatafora, M. Ferraro, A. Tipa, A. M. Vignola, C. H. Mody, G. Bonsignore, M. Gjomarkaj (Palermo, Italy; Calgary, Canada). ICAM-1 is shed as dimers by a regulated mechanism from cells in the inflamed pleural space and is biologically active. Eur Respir J 2002; 20: Suppl. 38, 1415

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The role of inflammatory cells, adhesion molecules, intermediate filaments and chemokine receptors in the pathogenesis of nasal polyps
Source: Annual Congress 2011 - Asthma: risk factors and comorbidities
Year: 2011

Pleural LTB4 upregulates ICAM-1 molecules via STAT-1 activation on pleural mesothelial cells
Source: Eur Respir J 2004; 24: Suppl. 48, 718s
Year: 2004

The release of PGE2 by pleural macrophages prolongs the survival of T lymphocytes within the inflamed human pleural space
Source: Eur Respir J 2005; 26: Suppl. 49, 346s
Year: 2005

Forced chemokine ligand 2 overexpression renders melanoma cells capable of inducing experimental malignant pleural effusion
Source: Annual Congress 2008 - Novel trends in functional genomics and molecular pathology of neoplastic and non-neoplastic lung diseases
Year: 2008

Neutrophil extracellular trap formation is regulated by CXCR2 in COPD neutrophils
Source: Eur Respir J, 51 (4) 1700970; 10.1183/13993003.00970-2017
Year: 2018



Alveolar macrophages activate STAT3 in epithelial cells via gp130 dependant steroid insensitive mechanism
Source: Annual Congress 2013 –Macrophages, mononuclear cells and viral infection
Year: 2013

Tobacco smoke induces muc5AC expression in normal bronchial epithelial cells trough activation of the NADPH system in a mechanism involving EGF-R activation
Source: Annual Congress 2009 - Translational models of lung disease
Year: 2009



MSC extracellular vesicles modulate human macrophages in ARDS towards anti-inflammatory phenotype via transfer of miRNA181-a and PTEN-pSTAT5-SOCS1 signalling
Source: Virtual Congress 2021 – Cellular and molecular involvement in lung injury and repair
Year: 2021



CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II
Source: Eur Respir J 2003; 22: Suppl. 45, 78s
Year: 2003

Bronchial epithelial cells secrete an unknown factor that specifically activate inflammatory cytokine expression from neutrophils and peripheral blood mononuclear cells
Source: Annual Congress 2004 - Epithelial cells: critical regulation of pathogenic processes in disease
Year: 2004


Differential release and deposition of S100A8/A9 proteins in inflamed upper airway tissue
Source: Eur Respir J 2016; 47: 264-274
Year: 2016



Increased levels of soluble intercellular adhesion molecule 1 in active smokers
Source: Annual Congress 2012 - Inflammatory mechanisms in COPD
Year: 2012

Pro-inflammtory effects of poorly soluble particles in human lung epithelial cells are dependent on surface area and surface reactivity
Source: Eur Respir J 2002; 20: Suppl. 38, 97s
Year: 2002

UR-13484, an orally active small molecule VLA-4 inhibitor that reduces lung inflammation
Source: Eur Respir J 2004; 24: Suppl. 48, 218s
Year: 2004

Nintedanib prevents IL-6-mediated secretion of CCL-18 in alternatively activated macrophages and transition of fibroblasts to myofibroblasts
Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis
Year: 2017

How T-lymphocytes are activated and become activators by cell-cell interaction
Source: Eur Respir J 2003; 22: 10S-15S
Year: 2003


Adhesion molecules and extracellular matrix proteins in co-cultures of airway epithelial cells and fibroblasts
Source: Annual Congress 2008 - Border patrol: the alveolar barrier in lung injury
Year: 2008


Trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles
Source: Eur Respir J 2005; 26: Suppl. 49, 730s
Year: 2005

PAR-2 mediated interactions between mast cells and fibroblasts cause a switch in fibroblast morphology and cytokine profile
Source: International Congress 2019 – New mechanistic insights into pulmonary fibrosis
Year: 2019

CCL5 (RANTES) inhibits TGF-β1-induced collagen production in human bronchial epithelial cells by action of Smad protein
Source: Annual Congress 2009 - New results in molecular pathology and functional genomics of non-neoplastic lung diseases
Year: 2009