Alveolar macrophages are a more important source of active IL-18 compared to dendritic or monocyte cells in the presence of the bacterial virulence factor SipB

C. Obregon, D. Dreher, M. Kok, L. Cochand, L. P. Nicod (Geneva, Switzerland)

Source: Annual Congress 2002 - Biology of immune recognition
Session: Biology of immune recognition
Session type: Oral Presentation
Number: 1412
Disease area: Respiratory infections

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Obregon, D. Dreher, M. Kok, L. Cochand, L. P. Nicod (Geneva, Switzerland). Alveolar macrophages are a more important source of active IL-18 compared to dendritic or monocyte cells in the presence of the bacterial virulence factor SipB. Eur Respir J 2002; 20: Suppl. 38, 1412

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Human neutrophil peptides stimulate the production of TNF alpha by alveolar macrophages from patients with sarcoidosis
Source: Annual Congress 2007 - Inflammatory cell biology
Year: 2007


Pattern recognition receptor expression and LPS binding capacity of human monocytes and alveolar macrophages
Source: Eur Respir J 2002; 20: Suppl. 38, 591s
Year: 2002

Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 521s
Year: 2001

IL-18, a novel Th1 cytokine, is up-regulated in pulmonary tuberculosis: expression and production by alveolar epithelial cells type II
Source: Eur Respir J 2002; 20: Suppl. 38, 213s
Year: 2002

Increased SDF-1alpha production from alveolar macrophages in sarcoidosis in vitro
Source: Annual Congress 2008 - Sarcoidosis: pathophysiology and severity
Year: 2008

Bronchial epithelial cells secrete an unknown factor that specifically activate inflammatory cytokine expression from neutrophils and peripheral blood mononuclear cells
Source: Annual Congress 2004 - Epithelial cells: critical regulation of pathogenic processes in disease
Year: 2004


Human alveolar macrophages express the chemokin PF-4 in tuberculosis
Source: Eur Respir J 2006; 28: Suppl. 50, 142s
Year: 2006

Regulation of human adult primary alveolar type II cell surfactant protein production by epithelial growth factors and pro-inflammatory cytokines
Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation
Year: 2009


Histamine-stimulated monocytes release microparticles that upregulate IL-8 synthesis by human alveolar epithelial cells
Source: Eur Respir J 2006; 28: Suppl. 50, 228s
Year: 2006

Bacterial load and defective monocyte-derived macrophage bacterial phagocytosis in biomass smoke-related COPD
Source: Eur Respir J, 53 (2) 1702273; 10.1183/13993003.02273-2017
Year: 2019



TLR-4 downregulation in COPD impairs cytokine release from monocytes and Th1-lymphocytes in response to bacterial endotoxin
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009


Late-breaking abstract: Activation of the macrophage inflammasome by TLR3 ligation potentiates release of IL-8 and IP-10 from alveolar type II epithelial cells via a paracrine cytokine network
Source: Annual Congress 2011 - Epithelial cells: role in health and disease
Year: 2011

Protein S inhibits the secretion of inflammatory cytokines from alveolar epithelial cells
Source: Annual Congress 2008 - Structural remodelling in COPD
Year: 2008

Endotoxin-induced IL-17 release by murine T-lymphocytes: interactions with airway macrophages
Source: Eur Respir J 2001; 18: Suppl. 33, 408s
Year: 2001

Glucocorticoids induce a shift in chemokine profile in LPS-stimulated human alveolar macrophages
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018

Monocyte derived microparticles upregulate IL-8, MCP-1, and ICAM-1 expression by human alveolar epithelial cells
Source: Eur Respir J 2005; 26: Suppl. 49, 26s
Year: 2005

Oxidative burst in lipopolysaccharide-activated human alveolar macrophages is inhibited by interleukin-9
Source: Eur Respir J 2002; 20: 1198-1205
Year: 2002



IL-6 and IL-8 production induced by Pseudomonas aeruginosa flagellin in human bronchial epithelial cells.
Source: International Congress 2017 – Infection and exacerbation science
Year: 2017


Differentiation of bronchial epithelial cells in the presence of Th2 cytokines increases the expression of the human cathelicidin hCAP18/LL-37
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Effect of JQ-1 on monocyte-derived macrophage (MDM) phagocytosis of bacteria and cytokine release
Source: Annual Congress 2013 –Macrophages, mononuclear cells and viral infection
Year: 2013