Source: Annual Congress 2002 - Bronchial responsiveness in asthma and COPD
Disease area: Airway diseases

Abstract

Exposure in a swine confinement building causes an intense airway inflammation with increased bronchial responsiveness in healthy subjects. Wearing a half-mask during exposure inhibits the inflammation but not fully the increase in bronchial responsiveness. This result suggests that gases may be responsible for bronchial responsiveness following swine house exposure.
Twelve healthy subjects were exposed to ammonia in an exposure-chamber at three different concentrations: 0, 5 and 25 ppm. Subjects were exposed for three hours, half time resting and the other time cycling (50W). Bronchial responsiveness to methacholine, lung function and exhaled NO were measured 7 hours after exposure.
PD20FEV1 was 1.91 (0.92-12.6)mg before exposure, 1.72 (0.46-3.26)mg, 0.95 (0.49-4.06)mg and 1.52 (0.88-2.31)mg after 0, 5 and 25 ppm ammonia exposure, respectively. There were significant differences in PD20 when pre- and post-exposure values were compared (p=0.05, p=0.003 and p=0.03, respectively) but not when 0 ppm was compared to 5 and 25 ppm (p=0.79 and p=0.58). The exposure did not influence lung function and NO.
In conclusion, inhalation of ammonia did not cause an increase of bronchial responsiveness following dust exposure. The observed increase in PD20 values is probably an effect of staying and exercising in the exposure-chamber.

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B. M. Sundblad, B. M. Larsson, L. Ernstgard, K. Larsson (Stockholm, Sweden). Airway responsiveness in healthy subjects following exposure to ammonia. Eur Respir J 2002; 20: Suppl. 38, 1201

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