Source: Annual Congress 2002 - Bronchial responsiveness in asthma and COPD
Disease area: Airway diseases

Abstract

Eosinophilic airway inflammation may be involved in the perception of dyspnea in asthma. In this study we investigated the effect of allergen exposure on the perception of bronchoconstriction induded by methacholine. Eleven steroid free mild asthmatics showing late asthmatic reaction, FEV1 84.4% predicted, PC20 mean 2.06 mg/ml underwent methacholine challenge(PC20 and PC35) and induction of sputum 5-7 days before and 24 hours after allergen challenge. Dyspnea perception was analysed as the ratio Borg score variation/FEV1 variation during the methacholine tests. Eosinophils in sputum increased from 1.92% to 8.62% following allergen challenge. PC20 and PC35 did not change.There was a decrease in the ratio Breathing Discomfort Score variation/FEV1 variation from 1.53 to 1.04 (P<0.05). Dyspnea perception indexes did not correlate with sputum eosinophils, PC20 or with the magnitute of the late asthmatic response. We did not find any correlation between Borg Scores and FEV1% predicted, suggesting that additional factors other than the bronchoconstriction must be involved in the perception of dyspnea. It is possible that airway inflammation may decrease the perception of dyspnea in asthmatic subjects.

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Citations should be made in the following way:
W. L. Mattos, S. Lim, P. J. Barnes (Porto Alegre, Brazil; London, United Kingdom). Airway inflammation and dyspnea perception. Effect of allergen exposure. Eur Respir J 2002; 20: Suppl. 38, 1200

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