Source: Annual Congress 2002 - Bronchial responsiveness in asthma and COPD
Disease area: Airway diseases

Abstract

Our aim was to compare bronchial responses according to the particle size of droplets carrying major cat allergen (Fel d 1) in intermittent asthmatics sensitized to cat. 3 nebulizers were selected with MMAD of 1.4, 4.8 and 10.3 μm. Allergen concentration was calculated to obtain the same amount of Fel d 1 per inhaled dose. A dosimeter Spira Elektro II nebulizer was used. For each patient, cat BCTs were performed blindly on 3 occasions with 3 nebulizers randomly selected. A metacholine BCT was performed 24 hours before cat BCT. 19 patients were selected, 11 women and 8 men, mean age 27 years, comparable to themselves in terms of NSBHR, FEV1, FEF25-75, PEF and dyspnea Borg scale before the 3 cat BCTs. PD20 cat allergen was 441 ng of Fel d 1 with the 1.4 μm nebulizer, 82 ng with the 4.8 μm nebulizer and 22.5 ng with the 10.3 μm nebulizer (p=0.001). On the other hand, inhalation of small particles caused a more severe fall in FEF25-75 24 hours after cat BCT than large particles (p=0.006). In conclusion, immediate bronchial response seems to be localized in large airways. It seems more appropriate to perform BCT with large particles carrying allergens.
This study was supported in part by 3M Sante, the Conseil Regional Alsace and the Hopitaux Universitaires of Strasbourg.

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F. Lieutier-Colas, A. Purohit, J. F. Fabries, M. C. Kopferschmitt, P. Meyer, J. F. Dessanges, G. Pauli, F. de Blay (Strasbourg, Nancy, Paris, France). Bronchial challenge tests in asthmatics sensitized to cat: importance of large particles in immediate bronchial response. Eur Respir J 2002; 20: Suppl. 38, 1199

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