Questionnaire responses that predict airway response to hypertonic saline
J. D. Leuppi, J. D. Brannan, E. G. Belousova, L. T. Rodwell, S. D. Anderson (Basel, Switzerland; Camperdown, Australia)
Source: Annual Congress 2002 - Bronchial responsiveness in asthma and COPD
Session: Bronchial responsiveness in asthma and COPD
Session type: Poster Discussion
Number: 1197
Disease area: Airway diseases
Abstract We investigated if responsiveness to hypertonic saline was predicted by asthma symptoms in the last 3 months. Patients being assessed for asthma severity (n=395), and subjects with a history of asthma who wished to dive with SCUBA (n=212) were studied. Bronchial provocation with 4.5% was performed and a questionnaire was administered. The response to 4.5% saline was reported as the provoking dose to cause a 15% fall in FEV1 (PD15) and the response-dose ratio. A PD15 to 4.5% saline was recorded in 234 of the 604, including 54 potential divers. Questions on 'self recognition of asthma', 'dust as a trigger', 'food as a trigger', and 'frequency of bronchodilator use' were significant predictors for a PD15, and 'currently taking steroids' decreased the likelihood of a positive response to 4.5% saline. Using a multiple-linear regression model, a difference in the response-dose ratio in those who answered positively compared with the reference group, who answered negatively, could be calculated and used as a guide for predicting reactivity. An increase in response-dose ratio in response to 4.5% saline, compared with the reference group, was demonstrated in the presence of 'self recognition of asthma severity', 'dust' and 'cats' as a trigger or 'use of bronchodilator during sleep hours'.
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J. D. Leuppi, J. D. Brannan, E. G. Belousova, L. T. Rodwell, S. D. Anderson (Basel, Switzerland; Camperdown, Australia). Questionnaire responses that predict airway response to hypertonic saline. Eur Respir J 2002; 20: Suppl. 38, 1197
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