Source: Annual Congress 2002 - Bronchial responsiveness in asthma and COPD
Disease area: Airway diseases

Abstract

The aim of this study was to investigate the cough sensitivity to capsaicin in patients with clinical symptoms of atopy localised in upper airways and skin. The cough sensitivity was defined as the lowest capsaicin concentration, which evoked 2 or more coughs and was expressed as geometric mean (95% CI) of capsaicin concentration. 15 patients with allergic rhinitis investigated out of pollen season (10 M, 5 F; mean age 30 yr.), 11 patients (3 M, 8 F; mean age 32 yr.) with symptom-free atopic dermatitis and 24 healthy volunteers (14 M, 10 F; mean age 37 yr.) inhaled deep breath (2 l) of capsaicin aerosol in doubled concentrations (from 0.02 to 200 μM) (Pari Provokationstest I, mass median diameter 1.2 μm). Cough sensitivity was significantly increased in patients with allergic rhinitis and atopic dermatitis, as well, in comparison with healthy subjects [0.84 μM (0.14-5.20) vs. 0.27 μM (0.04-1.85) vs. 4.29 μM (2.54-7.26); p < 0.05]. There was no significant difference in cough sensitivity between patients with allergic rhinitis and atopic dermatitis.
Conclusion: Cough sensitivity in patients with allergic rhinitis and atopic dermatitis is significantly increased nevertheless there were no clinical symptoms from lower airways.

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Citations should be made in the following way:
R. Pecova, J. Pec, M. Vrlik, Z. Frlickova, M. Tatar (Martin, Slovakia). Cough sensitivity changes in allergic rhinitis and atopic dermatitis without clinical symptoms from lower airways. Eur Respir J 2002; 20: Suppl. 38, 1195

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