Source: Annual Congress 2002 - Thoracic oncology: clinical management
Disease area: Thoracic oncology

Abstract

We have previously found a possible association between gender and prognosis in NSCLC stage I patients, showing a better survival rate among females (Eur Respir J 2001; 18: 229s). The purpose of this study was to further clarify the role of gender as a possible prognostic factor in NSCLC. In a retrospective cohort study, we have evaluated the survival of 103 NSCLC patients who underwent surgical curative treatment at PUCRS Hospital between 1990-1996. Data were analyzed by Kaplan-Meier curves. Additionally, we used Cox regression to adjust for potential confounding factors. There were 70 (68%) males and the mean follow-up was 52.2 + or - 41.4 months. Overall survival at 60 months was 47.5%. When analyzed separately by gender the survival rate of stage I patients was 94.7% and 51.5% for women and men, respectively (p = 0.009). The gender effect was still present after analysis of several factors (gender, age, hemoglobin, histologic type, tumor size, and postoperative complications) by Cox regression. The hazard ratio in women was 0.12 (CI90%: 0.04-0.37, p = 0.002) when compared to men. This study confirms our previous findings that for patients in early stage of NSCLC, female gender may have a protective effect, since women had a higher survival rate than men.

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J. M. Chatkin, C. M. Abreu, T. O. Crossetti, J. A. Pinto, G. Chatkin, M. Wagner, D. A. Padilha, C. C. Fritscher (Porto Alegre, Brazil). Is gender a prognostic factor in long term survival non-small cell lung cancer?. Eur Respir J 2002; 20: Suppl. 38, 1183

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