Source: Annual Congress 2002 - Thoracic oncology: clinical management
Disease area: Thoracic oncology

Abstract

The aim of the study was to investigate the significance of hormonal receptors in survival of patients with Non-small cell lung cancer. Patients and methods: In 59 patients (36 with squamous cell carcinoma, 18 with adenocarcinoma, mean age 58.4±]7,6) with operable non small-cell lung cancer (NSCLC), we identified three types of hormonal receptors Androgenic, Estrogenic and Progesteronic in lung tumor tissue, and in the adjacent normal lung, after surgical tumor resection. The first operation has been performed in 18/1/1989 and the last one in 23/2 1992 (median survival 701±]105,8, 95% CI 439,5-908,5 days) The method used was the dextrane-covered carbon one. Patients was separated in two groups Group A: 29 patients with sort term survival STS < 700 days mean survival 322.03±]187.3 days and Group B: 30 patients with Long-term survival (LTS) > 700 days mean survival 2057±]1278 days. Patients with LTS had statistically significant lower titre of oestrogen receptors of normal tissue compared with those with STS (2,1±]4,1 VS 6,87±]11,8 respectively p=0,42 unpaired student t-test) Nine patients are still alive (8 out of 36 with squamous cell carcinoma 29.6%; 1 out of 18 with adenocarcinoma 12,5 %). Patients with adenocarrcinoma had a statistically significant correlation between their survival time and titre of progesterone normal, androgenic normal and androgenic tumor receptors (r=0,56, p=0,019, r=0,47, p=0,055 and r=0,59, p=0,013 respectively, Pearson bivateral correlation). In conclusion the titre of progesterone adjacent normal tissue receptors, androgenic tumor tissue and normal tissue receptors are positively correlated with the survival of patients with adenocarcinoma.

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T. N. Kontakiotis, A. Paapazoglou, O. Antonoglou, P. Spyrou, M. Christoforidis, L. Sakas, T. Kostandinidis, D. Papakosta, K. Zarogoulidis, D. Patakas (Thessaloniki, Greece). Long term survival after resection for non small cell lung cancer significance of hormonal receptors. Eur Respir J 2002; 20: Suppl. 38, 1181

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