Fluorescence bronchoscopy for detection of clinically significant lesions
M. Bruyneel, P. Pierard, B. Martin, J. M. Verdebout, J. Faber, J. Hutsebaut, M. Richez, J. P. Sculier, V. Ninane (Brussels, Charleroi, Belgium)
Source: Annual Congress 2002 - Thoracic oncology: clinical management
Session: Thoracic oncology: clinical management
Session type: Poster Discussion
Number: 1176
Disease area: Thoracic oncology
Abstract We assessed whether autofluorescence bronchoscopy (AFB) enhances our ability to detect clinically significant lesions corresponding to severe dysplasia (DYS S), carcinoma in situ (CIS) and roentgenographically occult micro-invasive or invasive squamous cell carcinoma (CIV). Data prospectively collected in all the high-risk patients evaluated in our AFB unit between 01.01.96 and 31.12.01 were retrospectively analysed. White-light bronchoscopy (WLB) was followed by AFB and areas suspected of corresponding to preneoplastic lesions, CIS or CIV were recorded. All the biopsy specimens were reviewed by two pathologists. During the six years period, 1344 AFB were performed in 757 patients. 3869 areas were biopsied and included 82 lesions corresponding to DYS S or worse. 28 of them had been referred for evaluation and were excluded from analysis. 54 of them were detected in the unit (13 DYS S, 29 CIS, 12 CIV) and 14 of them (26%) were visible during AFB only. 12 lesions that appeared as abnormal during WLB in our unit had however been missed during a previous WLB in another unit. We conclude that, during WLB, lesions corresponding to DYS S or worse are visible to experienced AFB bronchoscopists 74% of the time but these visible lesions can be missed by other bronchoscopists.
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M. Bruyneel, P. Pierard, B. Martin, J. M. Verdebout, J. Faber, J. Hutsebaut, M. Richez, J. P. Sculier, V. Ninane (Brussels, Charleroi, Belgium). Fluorescence bronchoscopy for detection of clinically significant lesions. Eur Respir J 2002; 20: Suppl. 38, 1176
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