Source: Annual Congress 2002 - Physiotherapy: assessment and outcome in healthy subjects and patients with chronic lung disease
Disease area: Airway diseases

Abstract

Changes in respiratory drive, mechanics, muscle function, gas exchange and functional capacity are frequent in chronic renal failure (CRF) patients.AIMS: To characterize respiratory system and functional exercise capacity changes in CRF patients on hemodialysis treatment.
MATERIALS AND METHODS: Twelve patients (36.30±]10.20 years), undergoing hemodialysis (60.71±]56.42 months) were evaluated. Pulmonary function measurements were: forced vital capacity (FVC), forced expiratory volume in one second (FEV₁), FEV₁/FVC ratios, forced expiratory flow between 25% and 75% of the FVC (FEF_25-75%). Respiratory muscle strength was evaluated by measuring mouth pressures during maximum static inspiration (PI_max) and expiration (PE_max) pressures. Inspiratory and expiratory muscle endurance were measured with a continuous-incremental threshold loading test. The threshold pressure was raised at 5-min intervals by increment of 5 cmH₂O. The functional exercise capacity was determined by six-minute walking distance (6 MWD).
RESULTS: Pulmonary function test was normal and the values were computed as percentages of predict values (FVC: 88.47±]31.61%; FEV₁: 96.03±]33.86 %; FEV₁/ FVC: 75.64±]20.15%; FEF_25-75%: 83.73±]44.77% and MVV: 96.85±]29.69%). PI_max and PE_max were 106.53±]52.35% and 43.48±]14.50%, respectively. The total time and maximal tolerated load were 7.36±]8.34 min and 18.57±]7.44 cmH₂O; 5.24±]3.99 min and 11.42±]3.05 cmH₂O to the inspiratory and expiratory muscle endurance, respectively. Distance walked in 6 MWD was 68.93±]14.30 of predict.
CONCLUSION: These data indicate that there is an impairment of the expiratory muscle strength and endurance and exercise capacity determined by 6 MWD.

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M. D. G. Rodrigues-Machado, C. Cenachi-Coelho, A. P. S. Santos, I. M. Oliveira, G. L. L Machado-Coelho, S. S. Vilaça (Belo Horizonte, Ouro Preto, Brazil). Pulmonary function and six-minute walking distance in chronic renal failure patients on haemodialysis. Eur Respir J 2002; 20: Suppl. 38, 1173

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