Source: Annual Congress 2002 - Physiotherapy: assessment and outcome in healthy subjects and patients with chronic lung disease
Disease area: Airway diseases

Abstract

Introduction:
Non-invasive ventilatory support (NIVS) as well as supplementary oxygen (SO), provided during exercise, may result in improvement of exercise endurance in patients with COPD. The supposed working mechanisms differ. NIVS reduces inspiratory muscle work, whereas SO results in a lower minute ventilation. Aim of the present study was to test the hypothesis that the effect of NIVS plus SO on exercise endurance is significantly greater than the effect of NIVS alone.
Methods:
Twelve patients with COPD (FEV1=0.95 L.=37%pred.) were included. Exercise endurance on a cycle ergometer was measured during 3 submaximal exercise tests at 75% of Wmax. In random order tests were performed with 1. inspiratory pressure support of 5 cm H2O and an FiO2 of 21% (control session), 2. inspiratory pressure support of 10 cm H2O and an FiO2 of 21% (NIVS), 3. inspiratory pressure support of 10 cm H2O and an FiO2 of 30% (NIVS plus oxygen).
Results:
Exercise time
Control 270±]202 sec.
NIVS 430±]336 sec.*
NIVS plus SO 560±]359 sec.* #
* significantly different from control session. # significantly different from NIVS session
Conclusion:
SO added to NIVS during exercise has an extra effect on exercise endurance compared to NIVS alone in patients with COPD.

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Citations should be made in the following way:
A. Van't Hul, G. Kwakkel (Amsterdam, The Netherlands). The effects of non-invasive ventilatory support plus supplementary oxygen on exercise endurance in patients with COPD. Eur Respir J 2002; 20: Suppl. 38, 1170

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