Source: Annual Congress 2002 - Physiotherapy: assessment and outcome in healthy subjects and patients with chronic lung disease
Disease area: Airway diseases

Abstract

The nebulization is used as a treatment form and using a variety of medications to breathing disease. In although some studies have demonstrated a fall in the arterial oxygen saturation (SaO2) during the use of B2 adrenergic drug, there are few studies showed an aim to determine these drugs' effects in patients with COPD using ultra-sonic (US) or jet (JT) nebulizers (NBZs). Ten patients, carriers of moderate - severe COPD between 55 to 83 years-old were submitted to US and JT nebulization with bronchodilators in an alternate way.As a blind double study, one of the researchers chose in an aleatory way the nebulizer's type.The other one evaluated the parameters of SaO2, heart rate (HR), breathing rate (BR), and expiratory peak flow (EPF) before and after the procedure. The SaO2 varied in a significant way for NBZs (JT p=0,007 and US p=0,0018), but when comparing them, the SaO2 become similar (p=0,110). Regarding to HF, a similar behavior was observed after the use of NBZs, increasing in both devices in the first 15 minutes (JT p=0,032 and US p=0,012), without significant differences between the types of NBZ. BR didn't differ in both NBZs (JT p=0,439 and US p=0,259) after the nebulization. The EPF increase in JT (p=0,008) and US (p=0,005), and the gain obtained with Jet NBZ(JT 85.7 and US 56.9) this difference did not reach significance level (p=0,114). It was demonstrated that the administration of B2 agonist for the nebulization in patients with COPD, tend to shows a fall in the saturation in both types of NBZs without any alteration in BR
Support: UFPE/PIBIC/CNPq - *PIBIC/CNPq

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L. Matos, A. Dornelas de Andrade, B. Reis e Silva, P. Marinho, M. D. G. Rodrigues-Machado, N. Silva, R. Siqueira, N. Moraes, E. Silva Filho (Recife, Belo Horizonte, Brazil). Monitorization of β2-adrenergic effects in carriers of chronic obstructive pulmonary disease (COPD) using ultra-sonic and jet nebulization. Eur Respir J 2002; 20: Suppl. 38, 1163

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