Source: Annual Congress 2002 - Early influences on respiratory health and disease
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Introduction: The function of the β₂ Adrenergic Receptor (β₂ AR) is influenced by genetic polymorphisms ¹ and may effect asthma severity, bronchodilator response and the control of asthma ².
Aims: To investigate any influence of the codon 16 β₂AR polymorphisms on the severity and medium term outcome asthma in young children.
Methods: 44 symptomatic children (3.6-10.3 yrs) were assessed and followed for 11-27 months.
Results: 42 satisfactorily performed the interrupter technique (Rint) and 36 were successfully genotyped from buccal brushings. Non statistically significant trends for more severe disease were observed for the Gly allele. Smaller bronchodilator responses and deterioration in baseline Rint were associated with the Arg allele.
Discussion: The trends reported here require confirmation but suggest that the Gly allele may be associated with a more severe form of asthma in early childhood whereas the Arg allele may be associated with reduced bronchodilator responsiveness and deterioration of lung function over time. Is the Gly allele associated with more severe disease whereas the Arg allele and long term β agonist with deterioration?
Refs: 1. Green,S.A. et al. 1994 Biochemistry;33:9414-9419
2. Martinez,F.D. et al. J Clin Invest 1997;100:3184-8.

	Gly/Gly n=9	Gly/Arg n=22	Arg/Arg=5
Moderate/severe	6 (67%)	14 (65%)	1 (20%)
Baseline Rint Kpa/l/s	0.95(0.28)	0.80(0.32)	0.77(0.19)
β2 response>25%	6 (75%)	7 (35%)	2 (40%)
Improved Rint	5(63%)	8(38%)	2(40%)

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Citations should be made in the following way:
J. Black, H. Palmer, P. Helms, M. Main, D. Stewart (Aberdeen, United Kingdom). Do the codon 16 β₂ adrenoreceptor polymorphisms influence the severity and course of asthma in young children?. Eur Respir J 2002; 20: Suppl. 38, 1138

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