Source: Annual Congress 2002 - Early influences on respiratory health and disease
Disease area: Paediatric lung diseases

Abstract

Background There is conflicting evidence regarding the influence of maternal smoking in pregnancy on airway function in infancy.
Objective The aim of this study was to examine the association between peripheral airway function and fetal exposure to maternal smoking.
Methods We collated data from three published studies of airway function in infancy^1-3. Information was obtained for 355 infants (168 boys) in whom body size and maximal expiratory flow at functional residual capacity (V'_maxFRC) were measured on 601 occasions over the first 18 months of life. Maternal report of prenatal smoking was validated by cotinine assay. Data were analysed using multiple linear regression on square root transformed V'_maxFRC.
Results Body weight and length z-scores were significantly lower in infants whose mothers smoked in pregnancy (n=118). After adjustment for body size, V'_maxFRC was on average 25% lower in both girls (p = 0.0001) and boys (p=0.01) whose mothers smoked during pregnancy.
Interpretation Peripheral airway function is significantly impaired throughout the first 18 months of life in infants whose mothers smoked during pregnancy. This effect is apparent shortly after birth and is still evident after one year of age.
1. Hoo AF et al. Am.J.Respir.Crit.Care.Med. 2000; 161: A801
2. Hoo AF et al. Am.J.Respir.Crit.Care.Med. 1998; 158: 700-5
3. Tager IB et al. Am.J.Respir.Crit.Care.Med. 1995; 152: 977-83

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Citations should be made in the following way:
C. Dezateux, A. F. Hoo, T. Cole, J. Stocks, J. Hanrahan (London, United Kingdom; Boston, United States Of America). Influence of maternal smoking on peripheral airway function during the first 18 months of life. Eur Respir J 2002; 20: Suppl. 38, 1134

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