Source: Annual Congress 2002 - Interstitial lung disorders: markers of disease activity and severity
Disease area: Interstitial lung diseases

Abstract

Extravascular coagulation is associated with interstitial lung diseases (ILD) and promotes parenchyma fibrosis. We investigated the role of tissue factor (TF), protein C activity (APC) and D dimer in as well bronchoalveolar lavage fluid (BALF) as blood, which were obtained from 11 pts with pulmonary sarcoidosis (PS) and 10 pts with idiopathic pulmonary fibrosis (IPF). Measurements were provided using ELISA. Mean TF level was significantly higher in PS pts than in IPF pts: 634 ±] 126 pg/ml vs 489 ±] 135 pg/ml (BALF) and 184 ±] 53 pg/ml vs 149 ±] 28 pg/ml (blood). TF BALF/blood rate was 3,4 in both groups. BALF APC in both investigated groups was 0%, however blood APC was significantly higher in PS pts than in IPF pts (89,9 ±] 12,6% vs 77,2 ±] 9,6%). Mean D dimer level was significantly higher in PS pts than in IPF pts: 1500 ±] 1800 ng/ml vs 100 ±] 160 ng/ml (BALF) and 1800 ±] 1400 ng/ml vs 800 ±] 200 ng/ml (blood). D dimer BALF/blood rate was significantly higher in PS group than in IPF group: 0,8 vs 0,12. We found no correlation between coagulation factors and cell composition in BALF.We conclude that sarcoidosis and idiopathic pulmonary fibrosis provoke systemic, extra- and intravascular hyperactivity of coagulation. The study suggests the higher metabolic turnover of fibrinogen in sarcoidosis than in idiopathic pulmonary fibrosis.

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J. Talalaj, E. Chyczewska, M. Korniluk, M. Ossolinska (Bialystok, Poland). Coagulation activity of bronchoalveolar lavage fluid and blood in patients with interstitial lung diseases. Eur Respir J 2002; 20: Suppl. 38, 1122

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