Source: Annual Congress 2002 - Interstitial lung disorders: markers of disease activity and severity
Disease area: Interstitial lung diseases

Abstract

In the previous report we have demonstrated the association of IL-1 alpha -889 single nucleotide polymorphism with sarcoidosis in Czech population. We have, therefore, performed a pilot study to investigate if there was any relationship between this polymorphism and severity of pulmonary sarcoidosis as assessed by pulmonary function tests. In 67 patients with pulmonary sarcoidosis the pulmonary functions at presentation were evaluated by testing the following parameters: FEV1, FVC, FEV1/FVC, TLC, and DLco. Genotyping of IL-1 alpha -889 polymorphism in each patient was performed by PCR with sequence specific primers. The differences in pulmonary function data were tested by Mann-Whitney U test. In the group of sarcoidosis patients the lung function parameters were compared between carriers and non-carriers of the IL-1 alpha -889 allele 2 (genotypes 1.2 and 2.2 vs genotype 1.1). No statistically significant difference could be found between subjects with different genotypes. Based on the results of this pilot study, we conclude that although the IL-1 alpha -889 polymorphism is associated with susceptibility to sarcoidosis, this polymorphism is not related to the disease severity in Czech patients with sarcoidosis.
Grant support: GACR 310/99/1676 and MSM.15110002.

Rating:

Share or cite this content

Citations should be made in the following way:
B. Hutyrova, V. Kolek, R. M. du Bois, M. Petrek (Olomouc, Czech Republic; London, United Kingdom). IL-1α gene polymorphism in pulmonary sarcoidosis in relation to disease severity. Eur Respir J 2002; 20: Suppl. 38, 1115

Member's Comments

No comment yet.

Related content which might interest you: Angiotensin-converting-enzyme gene polymorphism and susceptibility to chronic obstructive pulmonary disease Source: Eur Respir J 2002; 20: Suppl. 38, 195s Year: 2002 CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis Source: Eur Respir J 2010; 35: 324-330 Year: 2010 VNTR polymorphism NOS3 gene among chronic obstructive pulmonary disease patients Source: Eur Respir J 2003; 22: Suppl. 45, 392s Year: 2003 The role of IL-18 level and genetic polymorphism in patients with bronchial asthma and its relation to disease severity Source: Annual Congress 2012 - Gene-environment treatment and asthma Year: 2012 The functional MUC5B rs35705950 promoter polymorphism is associated with IPF but not with systemic sclerosis related interstitial lung disease Source: Annual Congress 2012 - Idiopathic pulmonary fibrosis Year: 2012 Polymorphism of NRAMP1 gene in chronic obstructive pulmonary disease patients Source: Eur Respir J 2004; 24: Suppl. 48, 315s Year: 2004 A single nucleotide polymorphism in NOD2 gene was associated with pathogenesis and severity of COPD Source: Annual Congress 2010 - Genetics of obstruction Year: 2010 A BTNL2 gene variant confers to sarcoidosis susceptibility by an increased risk towards the chronic form of the disease Source: Eur Respir J 2006; 28: Suppl. 50, 148s Year: 2006 Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosis disease progression Source: Eur Respir J 2008; 32: 1004-1008 Year: 2008 Polymorphism of collagen I gene and glutation-S-transferases T1 and M1 in chronic obstructive pulmonary disease associated with cardiovascular disease Source: Annual Congress 2011 - New mechanisms in airway disease Year: 2011 Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients Source: Eur Respir J 2008; 32: 372-378 Year: 2008 Cryptogenic pulmonary fibrosis and gene polymorphism Source: Annual Congress 2007 - The role of gene polymorphisms in pulmonary disease susceptibility Year: 2007 Correlation of IL-1 alpha and IL-4 promotor region gene polymorphisms and clinical parameters in idiopathic pulmonary fibrosis Source: Annual Congress 2006 - Systemic diseases, environmental and genetic factors in interstitial lung disease Year: 2006 The relationship of IL-4 cytokine gene polymorphisms, HRCT and histopathological score in patients with idiopathic pulmonary fibrosis Source: Annual Congress 2011 - Genetic and molecular background in pulmonary fibrosis Year: 2011 Association of the 3A/4A (134delA) and Lys198Asn polymorphisms of the endothelin-1 gene with chronic obstructive pulmonary disease Source: Annual Congress 2008 - Novel trends in functional genomics and molecular pathology of neoplastic and non-neoplastic lung diseases Year: 2008 Relationship of the polymorphism Lys198Asn endothelin-1 gene with COPD and coronary heart disease. Source: Virtual Congress 2020 – Burden and predictive factors for chronic lung diseases and comorbidity Year: 2020 Systemic effects in patients with chronic obstructive pulmonary disease: a role of disease duration and disease severity Source: Annual Congress 2009 - Prognosis and comorbidities in COPD Year: 2009 IL8 as a marker of severity of disease progression in patients with idiopathic pulmonary fibrosis (IPF) Source: Eur Respir J 2007; 30: Suppl. 51, 373s Year: 2007 IFNL3 polymorphisms are associated with COPD severity and outcomes Source: International Congress 2017 – Towards personalised medicine in COPD: biological and clinical phenotypes Year: 2017 Polymorphic variants of genes ADRB2, NR3C1, MDR1 in patients with chronic obstructive pulmonary disease and obesity Source: International Congress 2015 – Genetics and environmental factors in phenotypes of asthma and COPD Year: 2015