Source: Annual Congress 2002 - Diagnosis of tuberculosis
Disease area: Respiratory infections

Abstract

OBJECTIVE:the present study aimed at evaluating the clinical utility and diagnostic efficacy of glutaraldehyde gelification test (GGT) as a simple, rapid, inexpensive and screening diagnostic technique for pulmonary tuberculosis.
METHODS: the study included 390 cases devided into 2 groups. group1(G1) consisted of 260 tuberclosis patients classified as: a) 110 newly diagnosed TB patients, b) 50 TB patients with sputum conversion to negative and good response to antituberculous treatment, c) 50 patients with persistent positive sputum for AFB after treatment, d) 50 cured TB patients. Group 2 (G2,the control group):included 130 cases:a) 50 patients with non-TB pulmonary infection,b)50 patients with non-infectious pulmonary disorders.c)30 healthy indivduals. GGT was performed for blood samples from all cases.The cutoff point of GGT was considered as 10 minutes.
RESULTS: The GGT was positive in 244 (86.15%) out of 260 TB patients. Positive results of 90%,82%,94% & 74% were observed among G1a,G1b,G1c & G1d respectively. However,16% of G2a & 44% of G2b patients reacted positively to the tes.GGT achieved senstivity of 86.15%,specificity of 76.92% & accuracy percent of 83.07%.There were a negative assosiation between the radiological extent of the disease and the time needed for gelification (p<0.05),and a significant difference between the mean values of gelification time for the three radiological grades(p<0.05).
CONCLUSION:The results of the present study suggest that GGT is a reliable , rapid, senstive method for initial screening of TB cases ,and the duration of gelification time may signify its use to asses disease extent and monitor response to treatment.

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Citations should be made in the following way:
M. A. Abourayan, A. A. Darwish, E. E. Hatata, A. M. El-Hefnawy (Alexandria, Menouffyia, Egypt). Clinical utility of glutaraldehyde gelification test as screening test for pulmonary tuberculosis. Eur Respir J 2002; 20: Suppl. 38, 1077

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