Source: Annual Congress 2002 - Diagnosis of tuberculosis
Disease area: Respiratory infections

Abstract

We used fiber bronchoscopy to obtain diagnostic specimens from lesion site in 77 TB patients with multiple negative results of microscopy and culture results with induced sputum. The following biopsy variants were used: bronchoalveolar lavage – 44 patients, brush-biopsy - 27 patients, transbronchial lung biopsy – 4 ones. For TB diagnosis the specimens obtained were studied cytologically, microbiologically, using microscopy and culture. M.tuberculosis were detected microscopically in 3 patients (3,9%) in specimens obtained with bronchoalveolar lavage and brush-biopsy. 14 patients (18,2%) were culture-positive. In 48 patients (62,3%) morphological sings of TB were detected with specimens obtained with brush- and transbronchial biopsy (caseous necrosis sites, epithelioid cell granulomas, gigantic multinucleate cells, lymphoid-macrophagal infiltration, calcium salts). Conclusion: Bronchoscopy and biopsy examinations are of value in the diagnosis of TB in sputum-negative patients. These techniques provide for the detection of mycobacteria in 18,2% cases and morphological confirmation of TB diagnosis in 62,3% in such cases. The use of different biopsy techniques for TB diagnosis in sputum-negative patients needs further study.

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Citations should be made in the following way:
N. V. Chernichenko, N. F. Sidorova, G. V. Evguschenko, I. Y. Shumskaya, O. V. Lovacheva (Moscow, Russia). Diagnostic value of bronchial biopsy specimens in the diagnosis of sputum-negative pulmonary tuberculosis (TB). Eur Respir J 2002; 20: Suppl. 38, 1062

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