Source: Annual Congress 2002 - The role of inflammatory markers in children with asthma
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Schoolchildren 13-14 year old (n = 959) were screened for asthma using the ISAAC questionnaire, additional questions, spirometry and measurement of the fraction of exhaled NO (FENO) using the Aerocrine NO system. Subjects with symptoms and laboratory indices of asthma were reinvestigated and a clinical judgement was made– asthma or not. A subgroup was defined of 22 subjects (cases) without asthma but elevated FENO, >15 ppb on two separate occasions or >20 ppb at one test. These cases were compared to 34 randomised controls with FENO below 5 ppb and no symptoms indicative of asthma. Cases were significantly more reactive to metacholine than controls (p=0.02) and ECP was higher in cases than controls both in sputum and serum (p<0.05, both). Neutrophil markers were of the same magnitude in both groups in induced sputum but in serum, levels of MPO were significantly lower (p<0.05) among cases than controls and HNL tended to be lower as well.
A group of cases with ongoing eosinophilic inflammation in the airways but without asthma symptoms exhibited subnormal systemic neutrophil activity.

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L. S. Nordvall, P. Kalm-Stephens, T. Foucard, K. Alving (Uppsala, Stockholm, Sweden). Bronchial inflammation without asthma symptoms, relation to low neutrophil activity in serum. Eur Respir J 2002; 20: Suppl. 38, 934

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