Source: Annual Congress 2002 - The role of inflammatory markers in children with asthma
Disease area: Airway diseases, Paediatric lung diseases

Abstract

During the last year the role of reactive oxygen forms in inflammation of the airways was the point of interest for many researchers. The aim of our study was to evaluate the presence of hydrogen perioxide in breath condesate of children with bronchial asthma of different severity. The quantity of hydrogen perioxide was assessed by spectrofluorometry using homovaniline acid and horseradish perioxidase. The highest levels of H2O2 were seen in children with severe asthma (mean±]SD 149.5±]92.4 uM/ml). The levels of H2O2 were statistically significantly higher than in control group of healthy children (n=13, H2O2=10.9±]14,2; p<0.001). In the group of children with severe asthma, besides the highest level of H2O2, also the ratio FEV1/FVC%pred was lower (87.1%±]11.3) compared to 104.8%±]7.4 in healthy ones. The evaluation of the level of H2O2 seems to be a sensitive method of assessing the activity of inflammatory processes in children's bronchial asthma.

Rating:

Share or cite this content

Citations should be made in the following way:
Z. Doniec, J. Gawel, W. Tomalak, R. Kurzawa (Rabka, Poland). Evaluation of hydrogen perioxide in breath condensate in children with bronchial asthma. Eur Respir J 2002; 20: Suppl. 38, 930

Member's Comments

No comment yet.

Related content which might interest you: Nitrite levels in breath condensate of children with bronchial asthma Source: Eur Respir J 2001; 18: Suppl. 33, 269s Year: 2001 The dynamic of pH, hydrogen peroxide and nitrite in exhaled breath condensate from patients with COPD and asthma exacerbation Source: Annual Congress 2010 - COPD: treatment and monitoring Year: 2010 The airways are the main source of hydrogen peroxide in exhaled breath condensate Source: Annual Congress 2010 - Exhaled biomarkers: smells like disease Year: 2010 Comparison between hydrogen peroxide and spirometry in airways inflammation of asthmatic children Source: Annual Congress 2008 - Paediatric airway diseases - pathophysiology and monitoring Year: 2008 Relationship between hydrogen peroxide levels in exhaled breath condensate and long term changes in small airway function of patients with asthma Source: Eur Respir J 2007; 30: Suppl. 51, 585s Year: 2007 Exercise increases the hydrogen peroxide release in exhaled breath condensate Source: Annual Congress 2012 - Exhaled biomarkers in airway diseases Year: 2012 Leukotrienes in exhaled breath condensate of children with asthma Source: Eur Respir J 2001; 18: Suppl. 33, 39s Year: 2001 The biomarkers of atopy in exhaled breath condensate in patients with bronchial asthma Source: Annual Congress 2010 - Biomarkers and Diagnosis of asthma and allergic respiratory diseases Year: 2010 Influence of smoking on indicators of free-radical oxidation in a condensate in exhaled breath condensate (EBC) at healthy and patients with bronchial asthma (BA) Source: Annual Congress 2010 - Smoking related disorders Year: 2010 Exhaled bronchial NO and cysteinyl-leukotrienes in breath condensate in atopic children Source: Eur Respir J 2002; 20: Suppl. 38, 412s Year: 2002 Concentrations of the hydrogen peroxide and nitrite in exhaled breath condensate as markers of inflammatory lung diseases Source: Annual Congress 2008 - COPD Year: 2008 Leukotrienes in exhaled breath condensate in childhood asthma Source: Eur Respir J 2003; 22: Suppl. 45, 398s Year: 2003 Exhaled breath condensate: hydrogen peroxide Source: Eur Respir Monogr 2010; 49: 162-172 Year: 2010 Cystenil-leukotrienes as markers of airway inflammation in exhaled breath condensate of asthmatic children Source: Eur Respir J 2002; 20: Suppl. 38, 412s Year: 2002 Prediction of asthma exacerbations in children by FeNO and non-invasive inflammatory markers in exhaled breath condensate Source: Annual Congress 2008 - Assessment of inflammation, hyperresponsiveness and response to exercise in asthmatic children Year: 2008 Profile of prostanoids in exhaled breath condensate in childhood asthma Source: Eur Respir J 2003; 22: Suppl. 45, 400s Year: 2003 Relationship between acidity of exhaled breath condensate, lung function and airway inflammation in asthmatic children Source: Annual Congress 2007 - Assessing asthma severity and control in children Year: 2007 Leukotrienes and 8-isoprostane in exhaled breath condensate of children with asymptomatic steroid-naive asthma Source: Annual Congress 2008 - Assessment of inflammation, hyperresponsiveness and response to exercise in asthmatic children Year: 2008 Hydrogen peroxide in expired breath condensate does not relate to severity in mechanically ventilated children Source: Eur Respir J 2002; 20: Suppl. 38, 532s Year: 2002