May antioxidants benefit recovery from acute asthma attack?
T. V. Zaharov, S. S. Pljaskic-Kamenov, H. T. Stamenkovic, V. B. Djordjevic, B. A. Kamenov (Pirot, Nis, Yugoslavia)
Source: Annual Congress 2002 - The role of inflammatory markers in children with asthma
Session: The role of inflammatory markers in children with asthma
Session type: Thematic Poster Session
Number: 929
Disease area: Airway diseases, Paediatric lung diseases
Abstract Introduction: From the point of possible deteriorating effect of free radicals, we have hypothesized that patients with different activity of serum antioxidants may have different recovery rates from asthma relapse. Methods: The serum content of nitric oxide (NO), catalase and gltathion peroxidase (GPx) were repeatedly assayed with light spectrophotometry in 21 asthmatic children (aged 5-15 god). Results: Patients with elevated concentration of NO were classified into 2 groups-with reduced (I group) and normal (II group) activity of antioxidant enzymes. Mean value of NO plasma levels in the first group was (143.33 ±]69.4 μmol/L ) and not significantly higher compared to the values of NO in the second group (105.135 ±]28.70μmol/L). The values of general catalase activity and GPx were significantly lower in the first group (CAT /g%:8.71 ±]2.10 U/gHbx104 ; GPx /gHb29.61 ±]4.89 U/gHb) compared to the second group (CAT /g%:13.545±]4.80U/gHbx104 ; GPx /gHb:51.435 ±]16.64 /gHb). Children of both groups did not show a significant difference in peakflow readings (76±]-6% vs. 73±]-5% of own best score, respectively). At comparable background medication, I group produced significantly better improvement in airflow performance than did the II group on day 5th (92±]-5% vs. 79±]-4%, P<0.05) Conclusions: GPx and catalase facilitate the recovery from asthma attack in children that prompts reevaluation of the role of antioxidant drugs in this condition. Antioxidants play a protective role by directly scavenging oxidants. Antioxidants may have a role in the treatment of asthma, counteracting effects of chronic oxidative stress.
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T. V. Zaharov, S. S. Pljaskic-Kamenov, H. T. Stamenkovic, V. B. Djordjevic, B. A. Kamenov (Pirot, Nis, Yugoslavia). May antioxidants benefit recovery from acute asthma attack?. Eur Respir J 2002; 20: Suppl. 38, 929
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