Correlation of exhaled nitric oxide with IgE levels and eosinophils in blood in pediatric asthma
F. Cardinale, E. Costantino, A. Polizzi, A. Calò, G. Tommasicchio, R. Cavallone, A. Nigro, M. S. Loffredo, G. Iacoviello, C. Caputo, I. Chinellato, L. Armenio (Bari, Italy)
Source: Annual Congress 2002 - The role of inflammatory markers in children with asthma
Session: The role of inflammatory markers in children with asthma
Session type: Thematic Poster Session
Number: 927
Disease area: Airway diseases, Paediatric lung diseases
Abstract Several studies have shown a variable degree of correlation of exhaled nitric oxide (ENO) with other markers of airway inflammation, namely eosinophils and eosinophil cationic protein, in asthma. However, raised levels of ENO have been reported mostly in skin-test positive asthma. On the other hand, both asthma risk and airway reactivity seem to be related to total IgE levels independently of the atopic status. We investigated the relationship between ENO, serum IgE levels and blood eosinophils in a population 45 mild (Mean [SD] FEV1 109% [11.2] pred) steroid-naive asthmatic children. ENO measurement was performed by a chemiluminescence analyzer (NOA TM 280, Sievers) according to ATS guidelines. Data regarding total IgE levels and blood eosinophil differential count were available in 27 out of 45 pts (60%). Among the 27 pts, 23 (85%) were skin test positive (>3 mm) for one ore more inhalant allergens. ENO levels in asthmatic patients were significantly higher as compared with a normal population (20 children) of non atopic children (Mean [SD] levels 37.6 [32.2] vs 7.3 [3.7] ppb: P<.0001). ENO levels showed significant correlation with total IgE (rs 0.476, P=.013), but not with eosinophil differential counts. A significant but weak correlation was also found between total IgE and eosinophils (rs 0.410, P=.03). We conclude that ENO levels and total IgE are correlated in a population of steroid-untreated mild asthmatic children. This relationship could depend from a common linked underlying factor. It could be also hypotesized that inflammatory changes in the airways may be the cause of the increase in both ENO and IgE levels.
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F. Cardinale, E. Costantino, A. Polizzi, A. Calò, G. Tommasicchio, R. Cavallone, A. Nigro, M. S. Loffredo, G. Iacoviello, C. Caputo, I. Chinellato, L. Armenio (Bari, Italy). Correlation of exhaled nitric oxide with IgE levels and eosinophils in blood in pediatric asthma. Eur Respir J 2002; 20: Suppl. 38, 927
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