Source: Annual Congress 2002 - The role of inflammatory markers in children with asthma
Disease area: Airway diseases

Abstract

Airway inflammation in severe asthma (SA) in not well characterized but may involve neutrophils. The aim of the study was to investigate bronchoalveolar lavage (BAL) cell profile, levels of IL-8, α1-proteinase inhibitor (α1-PI) and elastase activity in BALF of 10 children with SA (mean age 11,5±]0,4 years) in periods of marked clinical exacerbation (E) and relative clinical remission (R). Ten adult healthy controls were included for BAL procedure. We investigated that SA was characterized by a high median ratio of neutrophils (E - 12,25±]3,30%; R - 6,22±]1,81%; p<0,05), eosinophils (E - 10,41±]0,92%; 6,54±]0,55%; p<0,001) and lymphocytes (E - 17,33±]0,53%; R - 13,43±]0,65%; p<0,05) compared with healthy controls. We revealed high concentration of IL-8 in both exacerbation and remission (413,00±]67,32 pg/ml; 128,13±]30,52 pg/mg, respectively; p<0,005). Data from all SA patients demonstrated correlations between percentage of neutrophils and IL-8 (r=0,748; p<0,001). SA has characterized by increasing of elastase activity (EA) and high ratio EA/α1-PI compared to control patients (no free EA), furthermore ratio EA/α1-PI in exacerbation was significantly higher than in remission (p<0,05). We conclude that neutrophils and IL-8 are involved in pathogenesis of severe persistent asthma and protease/antiprotease imbalance takes place in airway inflammation in SA.

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A. V. Bogdanova, G. L. Muryghina, E. V. Boitsova, E. A. Surkova, T. P. Ses (St-Petersburg, Russia). Role of neutrophils in airway inflammation in children with severe persistent asthma. Eur Respir J 2002; 20: Suppl. 38, 925

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