Source: Annual Congress 2002 - Smoking habits in teenagers
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Parents[scquote] smoking is one of possible factors that can cause asthma in offspring. Intrauterine exposure to tobacco smoke metabolites has a direct effect on lung and airway development. Other reported effects include up regulation of T-helper cell (TH2) responses, possible increased IgE production and induction of inhalant allergy in children. We have tested parents whose children become affected by asthma (126 children: 46 female, 80 male, age 6-17 years - mean age 10.4 years). Exposure to tobacco smoke in utero was assessed retrospectively using questionnaire responses.
Obtained results (number of affected children, onset of asthma, intensity of tobacco exposure) are showed on the following table.

	Mother smoking	Father smoking	Both parents[scquote] smoking	Positive intrauterine exposure to tobacco smoke (one or both parents' smoking)	Negative intrauterine exposure to tobacco smoke (non-smoking parents)
Number of affected children	20 (15.87%)	52 (41.26%)	28 (22.22%)	100 (79.35%)	26 (20.63%)
Average time of onset of asthma (in months)	38	31.26	29.9	32.24	41.1
Average number of smoked cigarettes/24h	8.2	21	30.57	21.16	0

In group of asthmatic children in utero exposed to tobacco, onset of asthma was related to amount of tobacco smoke (number of smoked cigarettes/24h), no meter if smoker was mother or father.

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Citations should be made in the following way:
M. R. Slavkovic-Jovanovic, S. Zivanovic, L. Saranac, Z. Zivkovic (Nis, Belgrade, Yugoslavia). Effect of in utero tobacco smoke exposure on onset of asthma in offspring. Eur Respir J 2002; 20: Suppl. 38, 899

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