Source: Annual Congress 2002 - Exposure to chemicals
Disease area: Airway diseases

Abstract

Aims: Previous studies in 17 textile aerography workers involved in an outbreak, occurred in 1992 in Spain, suggested a persistent reactive airways dysfunction syndrome (Solé et al. Eur Respir J 1997; 164s). From a total workforce of 257, 112 workers in whom respiratory disease was suspected were referred to our Service for further evaluation. We have analyzed the changes in lung function and BHR in these textile aerography workers.
Material and methods: Initially, all participants had been away from work for at least one week prior to any testing. After a minimum of one year after stopping ocupational exposure and more than 3 months without any corticosteroid treatment, all pulmonary function tests were repeated using the same Masterlab assembly (Jaeger) and methaholine bronchial challenge protocol.
Results: Initially BHR was detected in 28/104 (27%)workers, with 8/31 cases (26%) exposed to Acramin FWN and 20/73 not exposed (27%). After a mean follow-up period of 10 months, 12/70 workers (17%) had BHR, including 7/17 (41%) exposed to Acramin FWN and 5/53 (9%) not exposed. The only functional parameter associated with persistent BHR was a lower FEV1/FVC ratio. In addition, mean PC20 was significantly lower in the first methacholine challenge test (12 mg/ml and 16 mg/dl, respectively).
Conclusions: BHR was lower after stopping exposure in textile aerography workers. Occupational exposure to Acramin FWN and lower FEV1/FVC ratio were associated with persistent BHR in textile aerography workers.

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V. Romero, L. Hernandez, J. Gil, J. Sanchez-Paya, C. Martín, S. Romero (Alicante, Spain). Evolution of bronchial hyperresponsiveness (BHR) in textile printing workers after stopping exposure. Eur Respir J 2002; 20: Suppl. 38, 860

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