Source: Annual Congress 2002 - Exposure to chemicals

Abstract

Aims: An epidemiological study has linked an outbreak of occupational lung disease in the textile industry in Spain with the use of a reformulated aerosolized product, Acramin FWN. Among 112 workers referred to our hospital in whom respiratory disease was suspected, 36 had been exposed to Acramin FWN. The aim of this study was to evaluate the prevalence of bronchial hyperresponsiveness (BHR) in these workers.
Material and methods: In eight patients was not possible to perform the methacholine bronchial challenge because of death or miscellaneous other reasons. All diagnostic techniques were performed before treatment was instaurated. All functional determinations were performed using a Masterlab assembly (Jaeger). Methacholine tests were performed according to standardized methodology using a Wright's nebuliser (output: 0.14 ml/min). The maximum methacholine concentration used was 50 mg/ml if a 20% fall in FEV1 had not been reached. A PC20 < 18 mg/ml was used to define significant BHR. Statistical analysis was performed using SPSS software.
Results: Initially, BHR was detected in 28/104 cases (27%), 8/31 exposed to Acramin FWN (26%)and 20/73 not exposed (27%),without differences between both groups. BHR was associated (p < 0,05) with younger age (<19 years) but not with functional test results or occupational factors.
Conclusions: 1.Prevalence of BHR in these workers was not higher than in general population 2. Younger age was a risk factor for BHR in textile workers.

AGE	BHR	NO BHR
Age [lte] 19	18 (39%)	28 (61%)
Age > 19	10 (17%)	48 (83%)

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Citations should be made in the following way:
V. Romero, L. Hernandez, S. Romero, J. Gil, J. Sanchez-Paya, I. Aranda (Alicante, Spain). Pulmonary function in textile printing workers. Influence of exposure to Acramin FWN. Eur Respir J 2002; 20: Suppl. 38, 859

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