Source: Annual Congress 2002 - Asbestos and silica
Disease area: Airway diseases

Abstract

Increased nonspecific bronchial hyperresponsiveness (NBHR) may be a risk factor for the development of chronic airflow obstruction. I evaluated this hypothesis in a cohort of 645 coal miners.
Spirometry and methacholine bronchial provocation test were performed twice. NBHR was observed in 18 miners in the first examination and in 30 miners in the second examination. Responsiveness status changed over time in 38 of subjects: in 13 reverted to normal and in 25 developed in the second examination. 5 miners had NBHR in both rounds. Mean annual FEV1 change in the group of miners with increasing NBHR was –22,6 ml/year. There were significant differences according to manifestation of NBHR. 13 miners with NBHR observed only in the first examination mean annual FEV1 change was -15,6 ml/year, in 25 miners with NBHR only in the second examination the rate was –32,6 ml/year. In miners hypersensitive in both examinations the annual FEV1 change was –17,4 ml/year.
Methacholine responders didn't have a considerably increased rate of FEV1 decline during the survey. Due to its variability over time, and to the rate of observed annual FEV1decline in miners with NBHR its value as a prognostic test for chronic airway disorders is limited.

Rating:

Share or cite this content

Citations should be made in the following way:
S. J. Ostrowski, W. Barud, A. Bilan, W. Myslinski, J. Mosiewicz, J. A. Hanzlik (Lublin, Poland). Nonspecific bronchial responsiveness and FEV1 decline in coal miners: 14 years follow up study. Eur Respir J 2002; 20: Suppl. 38, 851

Member's Comments

No comment yet.

Related content which might interest you: Lung function of Polish coalminers - normal spirometry after 20 years of dust exposure Source: Eur Respir J 2005; 26: Suppl. 49, 146s Year: 2005 FEV1 decline in occupational asthma Source: Eur Respir J 2003; 22: Suppl. 45, 488s Year: 2003 Effects of Asian dust events on peak expiratory flow and respiratory symptoms in subjects with bronchial asthma: a three month prospective study Source: Eur Respir J 2003; 22: Suppl. 45, 301s Year: 2003 FEV1 decline and eosinophilia in occupational asthma Source: Annual Congress 2011 - The work environment in the clinic Year: 2011 Cross-shift change and subsequent longitidinal changes in FEV1 in a 6 year follow-up study of wood dust exposed workers Source: Annual Congress 2012 - Asthma and COPD at work: what are the effects of exposure and risk factors? Year: 2012 Lung function decline, chronic bronchitis and occupational exposures during the follow-up of the ECRHS Source: Annual Congress 2005 - Better understanding of lung function decline and COPD Year: 2005 Sputum neutrophilia and annual decline of FEV1 in dust exposed workers Source: Annual Congress 2011 - Environmental exposure and disease mechanisms Year: 2011 Determinants of change in airway reactivity over 11 years in the SAPALDIA population study Source: Eur Respir J 2011; 37: 492-500 Year: 2011 Lower probability of FEV1 improvement in asthmatic children exposed to passive smoke Source: International Congress 2015 – Highlights in paediatric epidemiology: air pollution, asthma and primary ciliary dyskinesia Year: 2015 Early exposure to bio-contaminants and asthma up to 10 years of age: results of the HITEA study Source: Eur Respir J 2015; 45: 328-337 Year: 2015 Rate of FEV1 decline in workers with eosinophilic and non-eosinophilic occupational asthma Source: Eur Respir J 2007; 30: Suppl. 51, 155s Year: 2007 Incidence of probable occupational asthma and changes in airway calibre and responsiveness in apprentice welders Source: Eur Respir J 2003; 22: 513-518 Year: 2003 Respiratory symptoms, ventilatory function and bronchial responsiveness in workers exposed to cement dust Source: Annual Congress 2013 –Occupational respiratory diseases: obstructive, interstitial lung diseases and methods of diagnosis Year: 2013 Sputum eosinophilia and FEV1 decline in occupational asthma Source: Annual Congress 2008 - Asthma and inhalation injuries at work Year: 2008 Reducing the decline of FEV1 after a 4-year therapy with montelukast in patients with bronchial asthma Source: Annual Congress 2008 - Recent advances in the pathogenesis and treatment of asthma and COPD Year: 2008 Changes in FEV1 over 8 years in COPD Source: International Congress 2016 – Prevalence, prognosis, and risk factors of COPD Year: 2016 Relationship between bronchodilator response measured by FEV0.5 and methacholine provocation test in children from 3 to 15 years old Source: Annual Congress 2009 - Paediatric lung function, imaging and methodology in health and disease Year: 2009 Allergen exposure and the decline in pulmonary function in allergic asthmatic workers Source: Annual Congress 2008 - Understanding airway inflammation Year: 2008 Why is there often discordance between cross sectional and longitudinal studies of dust-induced COPD? Source: Annual Congress 2005 - Better understanding of lung function decline and COPD Year: 2005 Lung function, forced expiratory volume in 1 s decline and COPD hospitalisations over 44 years of follow-up Source: Eur Respir J 2016; 47: 742-750 Year: 2016