Morality predictors in acute exacerbation of idiopathic pulmonary fibrosis G. Dabar, M. Iskandar, B. Habr, Z. Aoun, M. Riachy, G. Khayat (Beirut, Lebanon)
Source: International Congress 2014 – ILDs 6
Session: ILDs 6 Session type: Thematic Poster Session Number: 3789
Disease area: Interstitial lung diseasesAbstract Background: Acute Exacerbation (AE) of Idiopathic Pulmonary Fibrosis (IPF) is the sudden acceleration of disease process superimposed on a diseased lung affected by IPF. Our objective is to find predictors of mortality in AE of IPF in our population.Design : Medical records review for the world pulmonary fibrosis from 2000 through 2012, followed by a manual review of the identified records that fit the criteria of AE of IPF. 71 patients with fibrosis were found. AE was identified in 30-discharge summary, 24 were analyzed and 6 medical records were missing.Setting: The studied patients were treated at the Hotel Dieu Hospital in Beirut by a group of pulmonologists without a predefined common protocol.Method: Data were collected from medical records and chest computerized tomography (CT) scans were reviewed.Statistical analysis: Pearson Chi-Square test was used to detect significant differences in patient's characteristics between survivors and non-survivors.Results: 18 exacerbation survived and 6 died, no difference was found in age, disease length, smoking, FVC, diffusion, infection 3 month prior to exacerbation. C-reactive protein (CRP) and Maximum oxygen use were significantly higher in the Non-survivors group while Procalcitonin or (+) sputum cultures were similar. CT scanner findings did not differ between the 2 groups. Patients who did not survive were more likely to have treatment limitation and stayed longer. A multivariable analysis included age, FVC, diffusion, CRP, maximal dose of steroids, and alveolitis, no correlation was found with mortality.Conclusion: In AE of IPF survivors and non-survivors had same characteristics, however higher CRP and resource utilization were noticed in non-survivors.Rating:
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G. Dabar, M. Iskandar, B. Habr, Z. Aoun, M. Riachy, G. Khayat (Beirut, Lebanon). Morality predictors in acute exacerbation of idiopathic pulmonary fibrosis. Eur Respir J 2014; 44: Suppl. 58, 3789
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