Source: Annual Congress 2002 - Epidemiology of asthma, rhinitis and allergy
Disease area: Airway diseases

Abstract

Objective: To study the association between LDS, MEF post challenge at 75, 50, and 25% FVC ±] peak flow (PEF) normalisation (division) and storage mites sensitisation in 1758 male Danish rurals aged 17-26 years.
Method: MEFV-curves were obtained and PEF, and flow at 75, 50, 25% FVC were recorded. Histamine responsiveness was measured by Yan method. FEV₁ and FVC were recorded. LDS was calculated as: ((FEV₁start - FEV₁end)*100/(FEV₁start*dose histamine given)+1). A skin prick test was pos. if the weal was >=3 mm.
Results: 114 subjects were prick test pos. to storage mites. Table 1 shows the difference in the means between prick test neg. and pos. with 95% CI of LDS, MEF at 75, 50, and 25% of FVC (NF75, NF50, NF25), and MEF, PEF normalised at 75, 50, and 25% of FVC (PNF75, PNF50, PNF25)(post challenge).

Indices	Difference in the means	95% CI
LDSFEV1	-0.11	-0.019- -0.201
NF75	0.27	-0.015- 0.555
NF50	0.20	-0.037- 0.437
NF25	0.07	-0.078- 0.218
PNF75	0.028	0.005- 0.051
PNF50	0.019	-0.007- 0.045
PNF25	0.006	0.012- 0.024

Conclusion: Whilst MEF were unable to discriminate bronchial responsiveness between prick test neg. and pos. to storage mites, LDS and MEF flow measured post challenge, PEF normalised at 75% FVC significantly did so. Differences in flow normalised to PEF might be a valuable alternative to LDS recording bronchial responsiveness in epidemiological studies.

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Citations should be made in the following way:
O. Omland, T. Sigsgaard, O. F. Pedersen, M. R. Miller (Aarhus, Aalborg, Denmark; Birmingham, United Kingdom). Bronchial responsiveness measured as log dose slope (LDS) and maximum expiratory flow (MEF) and sensitation to storage mites. Eur Respir J 2002; 20: Suppl. 38, 809

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