Source: Annual Congress 2002 - Epidemiology of asthma, rhinitis and allergy
Disease area: Airway diseases

Abstract

The European Community Respiratory Health Survey II (ECRHS II) is a multi-centre study investigating changes in the prevalence of asthma symptoms and risk factors for asthma, and is a follow-up study to ECRHS I conducted ten years ago. Key to these investigations is the measurement of atopy and the need to measure serum IgE levels using comparable methodology in both studies as, necessarily, ECRHS II is using a different and updated CAP System and different reagents to ECRHS I. To compare IgE measurements we re-assayed 636 serum samples from Ipswich and Norwich collected for ECRHS I. The table shows the ratio between geometric mean (GM) IgE measured in 1992 and 2001. As the values have increased, we compared the correlation within subjects to test whether this was due to evaporation of samples in the freezer. Results suggest that differences in equipment and/or allergen CAPs is the more likely explanation. To test the inherent variation in the assay we compared 174 duplicate IgE results from Ipswich and Norwich ECRHS II sera and found good agreement. This analysis indicates that serum IgE measurements are sufficiently reliable to allow comparisons of changes in the prevalence of atopy between centres and by risk factors in the ECRHS.

	GM in 1992	GM in 2001	Ratio (95% confidence interval)
Total IgE	34.30	49.76	1.45 (1.36-1.55)
D. pteronyssinus (d1)	0.72	0.81	1.12 (1.07-1.17)
Cat (e1)	0.48	0.50	1.05 (1.01-1.09)
Timothy grass (g6)	0.72	0.79	1.10 (1.05-1.14)
Cladosporium herbarum (m2)	0.38	0.38	1.00 (0.98-1.02)

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Citations should be made in the following way:
J. Potts, C. Luczynska, S. Chinn, D. Jarvis, P. Burney (London, United Kingdom). Comparison of IgE measurements using the pharmacia CAP systems in European community respiratory health surveys I and II. Eur Respir J 2002; 20: Suppl. 38, 808

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