The association between IgG seropositivity to microorganisms and the prevalence of allergic sensitisation to inhalant allergens in adult Danes
A. Linneberg, C. Østergaard, M. Tvede, L. Percival Andersen, A. Dirksen, F. Madsen, N. H. Nielsen, L. Frølund, T. Jørgensen (Copenhagen, Denmark)
Source: Annual Congress 2002 - Epidemiology of asthma, rhinitis and allergy
Session: Epidemiology of asthma, rhinitis and allergy
Session type: Thematic Poster Session
Number: 805
Disease area: Airway diseases
Abstract A few studies have indicated that colonisation of the gut with Clostridium difficile in early infancy predicts the development of atopy. This study aims to test this hypothesis by means of IgG seropositivity to Clostridium difficile as a proxy variable for previous colonisation with this bacteria. A cross-sectional population based study of 15-69-year-olds in Copenhagen was carried out in 1990. The participation rate was 77.5% (1112/1435). IgG seropositivity to Clostridium difficile, Campylobacter, Helicobacter, and Yersinia were measured by ELISA technique. Allergic sensitisation was defined as skin prick test positivity or specific IgE positivity to common inhalant allergens. The associations were analysed by age, a known significant determinant of both seropositivity to microorganisms and allergy. We found that seropositivity to Clostridium difficile (odds ratio 2.0, 95% CI 1.1-3.4) and Campylobacter (odds ratio 1.9, 95% CI 1.2-3.0) was significantly associated with allergic sensitisation among the youngest part of the population (15-34-year-olds). Seropositivity to Helicobacter was non-significantly negatively associated with allergic sensitisation (sex and age adjusted odds ratio 0.8, 95% CI 0.6-1.1). These data seem to support that the composition of the gut flora may have an influence on the development of allergic sensitisation.
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A. Linneberg, C. Østergaard, M. Tvede, L. Percival Andersen, A. Dirksen, F. Madsen, N. H. Nielsen, L. Frølund, T. Jørgensen (Copenhagen, Denmark). The association between IgG seropositivity to microorganisms and the prevalence of allergic sensitisation to inhalant allergens in adult Danes. Eur Respir J 2002; 20: Suppl. 38, 805
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