Source: Annual Congress 2002 - The development of allergic sensitization / asthma in children
Disease area: Airway diseases

Abstract

An inverse association between tuberculin responses and atopy has been reported. The increased incidence of exposure to Mycobacterium tuberculosis without clinical disease, may influence the T helper lymphocyte balance with decreased atopy as a result
Objective
To evaluate the relation between PPD test results and atopy in patients with bronchial asthma.
Methods
Study design: Prospective clinic study.
A hundered and thirty eight asthmatic (according to GINA criteria ) adults were enrolled into our study. Ninety two (66%) asthmatics were female, mean age and minimum –maximum range, 36±]10, (14-56) year, respectively and 46 (34%) asthmatics were male and mean age was 37±]10, (14-55) year. Duration of asthma, number of BCG scars, pric test results, specific Ig E as (+) or (-) results and jobs of patients were recorded. Five unit tuberculin were performed to all asthmatics and their results were evaluated within 48-72 hours and more than 10 mm enduration were accepted as a positive PPD results.
Results
PPD results for all asthmatics was 11,4±]7,0; (1-25) mm. According to PPD results patients were diveded into 3 groups: group I, 1-4 mm PPD; group II. 5-9 mm PPD; group III, ³10 mm PPD. The results of PPD in three groups as follows; group I, 1,1±]0,6 mm (n=30), group II, 7,4±]0,7 mm (n=17), group III. 15,6±]4,3 mm (n=91). The atopic and non-atopic asthmatics were 50.7% (n=70), 49,3 (n=68) respectively. There was significant and negative correlation between atopy and tuberculin response in asthmatics (r=-0.21, p=0.012).
Conclusions
In our clinic, there was a good negative correlation between atopy and PPD results in asthmatics.In our study suggest that it might be a protective way of development of atopy by exposing Mycobacterium tuberculosis in our asthmatic groups.

Rating:

Share or cite this content

Citations should be made in the following way:
T. Morali, Z. Karakurt, S. Bo[gu]a, A. Selvi, H. Türker (Istanbul, Turkey). Response to tuberculin test in patients with bronchial asthma. Eur Respir J 2002; 20: Suppl. 38, 785

Member's Comments

No comment yet.

Related content which might interest you: Tuberculin skin test sensivity in asthma patients Source: Annual Congress 2011 - Diagnosis and treatment of inflammatory respiratory diseases Year: 2011 Specific features of tuberculin sensitivity in children with bronchial asthma Source: Annual Congress 2009 - Tuberculosis at different age groups Year: 2009 The natural prognosis of atopy determined by skin prick test in patients with bronchial asthma and/or rhinitis Source: Eur Respir J 2001; 18: Suppl. 33, 368s Year: 2001 Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults Source: Eur Respir J 2014; 43: 92-102 Year: 2004 Methacholine challenge test in allergic rhinitis patients Source: Eur Respir J 2005; 26: Suppl. 49, 130s Year: 2005 Evaluation of tuberculin skin tests in patients with atopic dermatitis Source: Eur Respir J 2006; 28: Suppl. 50, 24s Year: 2006 Assessment of bronchoprovocation test positivity and response to montelukast theraphy in chronic urticaria patients Source: Eur Respir J 2006; 28: Suppl. 50, 445s Year: 2006 Airway hyperresponsiveness in asymptomatic subjects: is bronchial provocation with mannitol a more specific test? Source: Eur Respir J 2005; 26: Suppl. 49, 228s Year: 2005 Nasal provocation tests and bronchial hyperresponsivness in patients with perennial rhinitis Source: Eur Respir J 2002; 20: Suppl. 38, 218s Year: 2002 Predictors of methacholine responsiveness in a population of patients with suspected bronchial asthma Source: Eur Respir J 2003; 22: Suppl. 45, 295s Year: 2003 Relationship between asthma and frequency of allergic symptoms in school children with skin prick test Source: Eur Respir J 2005; 26: Suppl. 49, 682s Year: 2005 Bronchial challenge test in patients with chronic persistent cough and asthma Source: Eur Respir J 2003; 22: Suppl. 45, 475s Year: 2003 Evaluation of atopy by skin prick tests in asthma patients with and without rhinitis in central Anatolia Source: Eur Respir J 2007; 30: Suppl. 51, 628s Year: 2007 Bronchial hyperresponsiveness to methacholine and exercise, relation to allergy in asthma patients Source: Eur Respir J 2002; 20: Suppl. 38, 504s Year: 2002 Safety of segmental allergen challenge in human allergic asthma Source: Annual Congress 2007 - Novel aspects in airway inflammation in human asthma and rhinitis Year: 2007 Yield of a mannitol bronchial provocation test (BPT) for the diagnosis of asthma in a real-life study Source: International Congress 2015 – Any news from the asthma field? Year: 2015 Lung volumes before and after bronchial provocation test in asthmatic preschool children Source: Eur Respir J 2006; 28: Suppl. 50, 477s Year: 2006 The diagnostic value of nasal provocation tests in children with perennial allergic rhinitis Source: Eur Respir J 2006; 28: Suppl. 50, 483s Year: 2006 Bronchial challenge test and related factors in the presence of bronchial asthma and/or allergic rhinitis symptoms Source: Eur Respir J 2005; 26: Suppl. 49, 130s Year: 2005 Sensitivity of skin prick test and association between respiratory function tests in asthma patients followed for two years in Tokat Source: Eur Respir J 2006; 28: Suppl. 50, 232s Year: 2006