Source: Annual Congress 2002 - The development of allergic sensitization / asthma in children
Disease area: Airway diseases, Paediatric lung diseases

Abstract

It is well established that the induction of T-cell memory is frequently initiated in utero, and it is likely that maternal factors exert their influences during this period. We dynamically investigated immunological changes of 10 fetuses of atopic mothers (in most cases suffering bronchial asthma) at 22 to 37 weeks` gestation. In the control group were concluded 16 healthy fetuses. The fetal blood samples obtained by cordocentesis technique at the necessary to exclude a genetic pathology, congenital malformations, development hemolytic disease and/or during the premature labor. Enzyme-linked immunoassay was used to measure serum concentrations of interleukin (IL)-2 (Th1) and IL-4 (Th2). It was shown that the concentration of IL-2 in fetal plasma had approximately same low level during the second and third trimester of pregnancy in both normals and atopics. The increasing of IL-2 was revealed at the period of 37 weeks until the labors. The IL-4 has demonstrated the low level at 22-34 and 37-40 weeks with increased parameters during 34-37 weeks` gestation. The infants of asthmatic mothers had reduced IL-4 at birth. These findings support the hypothesis that the fetus maintains a Th1 biased environment to counteract the Th2 biased maternal and placental influences. The IL-2 can play the role in promotion of fetal rejection. So, understanding the underlying mechanisms whereby immunological responses are initiated and modified at the beginning of life can offer alternative targets for therapeutic intervention.

Rating:

Share or cite this content

Citations should be made in the following way:
J. V. Priamkova, G. A. Samsygina, I. G. Sherbakova, O. V. Zaitseva (Moscow, Russia). Fetal immune changes during atopy and normal pregnancies. Eur Respir J 2002; 20: Suppl. 38, 783

Member's Comments

No comment yet.

Related content which might interest you: Maternal atopy influences innate immune responses in neonatal cord blood Source: Eur Respir J 2005; 26: Suppl. 49, 9s Year: 2005 Prenatal influences on immune responses at birth Source: Annual Congress 2003 - Prenatal influences on asthma and atopy Year: 2003 Maternal preeclampsia and placental abruption and increased risk of atopy in male adolescent Source: Annual Congress 2009 - Novel approaches in asthma Year: 2009 Adverse effects of maternal smoking during pregnancy on innate immunity in infants Source: Eur Respir J 2006 Oct 01;28(4):675-677 Year: 2006 Maternal blood pressure throughout pregnancy, gestational hypertension, and preeclampsia and offspring asthma Source: International Congress 2019 – More and more COPD Year: 2019 A comparison of lung function and atopy between children with intrauterine growth retardation and normal birth weight in a birth cohort with documented wheeze Source: Annual Congress 2012 - Predicting and observing paediatric allergic disease Year: 2012 Alterations in measures of systemic inflammation among adults born preterm Source: International Congress 2019 – Chronic cough, a1-antitrypsin deficiency and other conditions Year: 2019 Role of Th 17 cells in neonates related to maternal atopy Source: Annual Congress 2008 - Assessment of inflammation, hyperresponsiveness and response to exercise in asthmatic children Year: 2008 Alterations of Th1/Th2 cytokine concentrations at fetuses of asthmatic mothers Source: Eur Respir J 2005; 26: Suppl. 49, 399s Year: 2005 Maternal atopy influences neonatal T cell function Source: Eur Respir J 2007; 30: Suppl. 51, 644s Year: 2007 The role of maternal bronchial asthma and pathology of pregnancy in the development of allergy in infancy Source: Eur Respir J 2006; 28: Suppl. 50, 235s Year: 2006 Respiratory symptoms and lung function in relation to atopy in children born preterm Source: Eur Respir J 2001; 18: Suppl. 33, 370s Year: 2001 Postnatal immune response of high-risk children for development of bronchial asthma Source: Eur Respir J 2002; 20: Suppl. 38, 144s Year: 2002 Maternal asthma and placental mast cell expression depending on asthma severity, fetal sex and presence of preeclampsia Source: International Congress 2015 – Asthma and lung immunology Year: 2015 Maturation of the immune system and development of immune responses to allergens Source: ISSN=1025-448x, ISBN=1-904097-22-7, page=25 Year: 2002 Concomitance of maternal asthma and preeclampsia and asthma risk in the offspring Source: International Congress 2019 – Asthma and the world Year: 2019 Maternal adiposity in pregnancy and offspring asthma in adulthood Source: Eur Respir J, 52 (2) 1801152; 10.1183/13993003.01152-2018 Year: 2018 Specific features of the pregnancy in bronchial asthma patients Source: Annual Congress 2005 - Asthma in pregnancy and menopause Year: 2005 The development of food allergy, the immunologic process from foetus to infant Source: Annual Congress 2005 - Food allergy, atopic dermatitis and asthma Year: 2005 Cord blood eosinophils and Type 2 Innate lymphoid cells are correlated in infants born to mothers with asthma during pregnancy Source: International Congress 2018 – New developments in paediatric asthma Year: 2018