Source: Annual Congress 2002 - The development of allergic sensitization / asthma in children
Disease area: Airway diseases

Abstract

Aim of the work was to establish pathogenesis relationship between bronchial asthma (BA) and minimal change nephrotic syndrome or idiopathic nephrotic syndrome (INS), in the childhood.
25 patients with BA and 32 patients with steroid-sensitive INS, from 2 to 10 years old were observed. The leading role of the autopic factor was supported by anamnesis data, by increased IgE in blood as well as by the intact complement system. Combination of BA and INS was detected in 5 cases. Treatment and prevention were provided by standard methods. No casual relationship was found between BA exacerbation and INS recidivating. The findings appeared to be identical both in the cases of BA and INS: against the background of normal values of helper/inductor CD3+ and CD8+ were decreased, the volume of phenotype immunoregulation index (CD4+/CD8+), was increased.
Thus, among various and many-component mechanisms of BA and INS development, IgE-dependent hyper-sensitivity is leading. General immunogenetic factors determining atopic allergy, result in cytomembranous destabilisation and change in tour bicelectronic charge in the whack organ (selective protinuria in INS and others). Participation of lungs and kidneys inpathologic processes is the result of the above mentioned process and the basis for clinical manifestation on medical preparations. While a different effect can be explained by participation of various mediators (cytokins) in this syndrome.

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Citations should be made in the following way:
G. Megrelishvili, N. Adamia, T. Davitaia, N. Manjavidze, K. Makashvili (Tbilisi, Georgia). Mechanism of minimal change development of bronchial asthma and nephritic syndrome in children. Eur Respir J 2002; 20: Suppl. 38, 782

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