Source: Annual Congress 2002 - The development of allergic sensitization / asthma in children
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Asthma is defined as a chronic inflammatory disorder of the airway mucosa. The aim of this study was to establish one or more inflammatory agents as a marker of disease activity in bronchial asthma. This study included 3 groups of children. Group A consisted of 35 children with asthma and FEV1<80% of predicted values, 24 boys, 11 girls, aged (mean age + SE) 9.3 + 0.4 years, Group B of 70 children with asthma and FEV1>80% of predictive normal values, 44 boys, 26 girls, aged 8.65 + 2.8 years and Group C of 48 healthy children, 33 boys, 15 girls, aged 10.73 + 0.38. In serum, levels of procalcitonin (PCT) by immunoluminescence, CRP by nephelometry and cytokines levels of IL-6, IL-8, IL-4 and IL-5 by ELISA were determined. The results as mean values + SE are shown in Table:

	Group A	Group B	Group C
CRP (mg/ml)	0.26+0.26	0.24+0.19	0.22+0.19
PCT μg/ml)	0.25+0.25	0.24+0.13	0.24+0.21
IL-1μ(pg/ml)	13.5+3.2	10.6+2.7	8.8+1.2
IL-6 (pg/ml)	2.1+0.6	1.7+0.3	1.2+0.3
IL-4 (pg/ml)	2.8+0.2	2.6+0.3	0.9+0.5
IL-5 (pg/ml)	30.2+3.1	29.8+2.9	8.1+1.5

Conclusions : CRP and PCT levels did not play any role in airway allergic inflammation while sera levels of inflammatory cytokines associated mainly with Th2 responses possible play a key role in airway allergic inflammation.

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M. Hatzistilianou, K. Haidopoulou, A. Rekliti, C. Aggouridaki, S. Karamperis, M. Eboriadou (Thessaloniki, Greece). Procalcitonin and inflammatory cytokines in children with asthma. Eur Respir J 2002; 20: Suppl. 38, 778

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