Source: Annual Congress 2002 - The development of allergic sensitization / asthma in children
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Childhood respiratory diseases complicated by recurrent respiratory tract infections may be associated with immune system deficiencies. Also, there have been reports noting different IgG subclass patterns in atopic disorders. The aim of this study was to investigate serum IgG subclass levels, IgA and IgM levels, serum IgE, number of peripheral blood CD lymphocyte markers in atopic and nonatopic children with recurrent respiratory tract infections. We recruited 49 children, aged 1 to 14 years, with at least six episodes of respiratory tract infections. Among this patients, 22 children were atopic, and 27 nonatopic. Comparison of the two groups in children with recurrent infections revealed significantly decreased serum IgG3 (p=0,008), and increased CD 4 given in percent of the total number of peripheral lymphocytes in the group of atopic children. Nonatopic children showed a high IgG1, IgG2 and IgG3 serum levels, and higher CD 3, CD 8, CD 19 and NK lymphocyte numbers. Among atopic children 16 had lower levels of IgG subclasses: 2 in IgG1, 8 in IgG2, and 6 in IgG3 (according to their age values). Among nonatopic children 8 had lower levels of IgG subclasses: 2 in IgG1, 4 in IgG2, and 2 in IgG3 (according to their age values).
In conclusion, among patients with recurrent respiratory infections, the atopic children present lower serum IgG3 levels, together with higher numbers of peripheral blood CD 4 lymphocytes than nonatopic children. These differences suggest two pathways of human immune regulation in atopic and nonatopic children.

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Citations should be made in the following way:
I. Stelmach, M. Podsiadlowicz-Borzecka, W. Stelmach, P. Majak, J. Jerzynska, P. Kuna (Zgierz, Lodz, Poland). Patterns of immune regulations in atopic and nonatopic children with recurrent respiratory tract infections. Eur Respir J 2002; 20: Suppl. 38, 776

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