Preschool exposure to traffic-related air pollution and small airway involvement in adolescence
E. S. Schultz, J. Hallberg, T. Bellander, A. Bergström, M. Bottai, F. Chiesa, P. M. Gustafsson, O. Gruzieva, P. Thunqvist, G. Pershagen, E. Melén (Stockholm, Gothenburg, Skövde, Sweden)
Source: International Congress 2014 – Longitudinal studies of respiratory disease
Session: Longitudinal studies of respiratory disease
Session type: Poster Discussion
Number: 2991
Disease area: Airway diseases, Paediatric lung diseases
Abstract Introduction: Air pollution exposure early in life has been related to lung function decrements in 8-year old children (Schultz et al AJRCCM 186(12):1286-91.), but whether the negative effect persists into adolescence is unknown.Aims and objectives: To analyze the relationship between long-term exposure to air pollution and small airway involvement measured with impulse oscillometry (IOS) at 16 years of age.Methods: 2416 children in the Swedish birth cohort BAMSE performed IOS at 16 years of age. Exposure to air pollution from road traffic was estimated (as nitrogen oxides (NOx )) for residential, daycare and school addresses from birth up to 16 years of age using an emission inventory and dispersion modelling. The relationship between a time-weighted average traffic-NOx exposure over different time windows and frequency dependence resistance (fdR; R5Hz-R20Hz) as well as square root of reactance area (AX) were analyzed by quantile regression on the median.Results: A 10 ɥg/m³ increase in first year of life exposure to traffic-NOx was associated with impaired lung function in all subjects (0.002 kP/L/s 95% CI: 0.0002 to 0.0036 p=0.025 for fdR and 0.005 (kP/L)1/2 95% CI: 0.0002 to 0.0106p=0.041 for AX) and in males separately (p=0.001 and p=0.057, respectively). Exposure during year 1 to 8 showed significant association with AX, but not with fdR. Later exposures showed no clear effects.Conclusions Our data indicate that exposure to traffic-related air pollution in preschool age is associated with impaired small airway function at 16 years of age.
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E. S. Schultz, J. Hallberg, T. Bellander, A. Bergström, M. Bottai, F. Chiesa, P. M. Gustafsson, O. Gruzieva, P. Thunqvist, G. Pershagen, E. Melén (Stockholm, Gothenburg, Skövde, Sweden). Preschool exposure to traffic-related air pollution and small airway involvement in adolescence. Eur Respir J 2014; 44: Suppl. 58, 2991
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