Source: International Congress 2014 – Longitudinal studies of respiratory disease
Disease area: Airway diseases

Abstract

BACKGROUND:A community-based prevalence survey performed in Cape Town in 2005, using the BOLD methodology reported a prevalence of COPD of 24% among adults aged >40 years.AIMS:To study the vital status and lung function in COPD subjects 5 years after their initial diagnosis in the BOLD survey.METHODS:Subjects identified with COPD in 2005 were invited to participate, and have spirometry repeated in 2010 using the same spirometers as in 2005.RESULTS:Forty-five (23%) of 196 eligible subjects had died since the 2005 survey: 8 of respiratory causes, 10 of cardiovascular and 6 of other known causes and in 21 the cause of death was not known. Only age and GOLD stage 4 disease (in 2005) were significantly associated with death on multivariate analysis. Of the survivors 11 (6%) had moved away; 33 (17%) declined or had medical exclusions (e.g. dementia); and 106 (54%) were included (median age 63y; 46% males).Post-bronchodilator spirometry did not confirm airflow limitation (AFL) defined as FEV1:FVC ratio < 0.7 in 16 of 106 (15%) subjects, while 90 (85%) showed AFL. The median decline in FEV1 was 28.9ml/yr (IQR: -54.8: 0.00ml/yr), with no difference between GOLD stages. The median decline in FVC was -75ml, and was significantly greater in GOLD stage 1 (-350ml) compared with GOLD stages 2 or 3 (-80ml & +140ml respectively; p<0.01). Fifty-eight (64%) subjects with AFL remained in the same GOLD stage, while 21 (23%) had deteriorated and 11 (12%) improved by ³1GOLD stage.CONCLUSIONS: Five-year follow-up of a BOLD COPD cohort revealed disease progression and high mortality. The BOLD definition and/or methodology was associated with overdiagnosis of COPD.

Rating:

Share or cite this content

Citations should be made in the following way:
B. Allwood, R. Gillespie, M. Bateman, H. Olckers, L. Taborda-Barata, G. Calligaro, R. Van Zyl-Smit, N. Beyers, E. Bateman (Cape Town, Stellenbosch, South Africa; Covilha, Portugal). Five-year follow-up of subjects diagnosed with COPD in a South African burden of obstructive lung disease (BOLD) survey. Eur Respir J 2014; 44: Suppl. 58, 2981

Member's Comments

No comment yet.

Related content which might interest you: The burden of obstructive lung disease (BOLD) methodology overestimates the prevalence of COPD: A 5-year follow-up study Source: International Congress 2014 – Prevalence of COPD and mortality from COPD Year: 2014 Characteristics of subjects susceptible to exacerbation-like respiratory events in a population-based cohort: Canadian cohort obstructive lung disease (CanCOLD) study Source: International Congress 2014 – Longitudinal studies of respiratory disease Year: 2014 Heterogeneity in prevalence and underdiagnosis of COPD: Results from BOLD, EPI-SCAN, PLATINO, and PREPOCOL Source: Annual Congress 2013 –Assessing the prevalence of COPD in the general population Year: 2013 COPD prevalence in Argentina: The EPOC.AR study Source: International Congress 2016 – Prevalence of obstructive airway diseases, methods of diagnosis, and lung function testing Year: 2016 An epidemiological study of chronic obstructive pulmonary disease (COPD) in a rural town of Japan: a one-year follow-up study Source: Eur Respir J 2006; 28: Suppl. 50, 448s Year: 2006 COPD in non-smokers: Report from the Tunisian burden of obstructive lung disease study Source: International Congress 2015 – Prevalence of respiratory disease Year: 2015 The bronchitic phenotype is related to morbidity and mortality - report from the OLIN COPD study Source: Annual Congress 2013 –Investigating COPD in longitudinal studies Year: 2013 COPD prevalence in Austria: results from the Burden of obstructive lung disease (BOLD) study Source: Eur Respir J 2006; 28: Suppl. 50, 446s Year: 2006 Population surveillance in North West Adelaide: the impact of diagnosed and undiagnosed chronic obstructive pulmonary disease (COPD) on quality of life Source: Eur Respir J 2005; 26: Suppl. 49, 383s Year: 2005 15-years mortality in asthma-COPD overlap syndrome (ACOS) elderly population Source: International Congress 2015 – Respiratory health across the life course Year: 2015 A population-based study of incidence of respiratory symptoms and asthma in relation to occupational group. A 10 years follow-up. Report from the obstructive lung disease in northern Sweden studies (OLIN) Source: Eur Respir J 2004; 24: Suppl. 48, 499s Year: 2004 Comparison of gender-related risk factors for COPD – Results from the Canadian obstructive lung disease (CanCOLD) study Source: Annual Congress 2013 –Factors associated with outcomes in COPD Year: 2013 Prevalence and incidence of COPD: The Rotterdam study Source: International Congress 2015 – Prevalence of respiratory disease Year: 2015 The characteristics of ACOS in a population based asthma cohort Source: International Congress 2016 – COPD and asthma COPD overlap syndrome (ACOS): novelties in terms of prevalence, risk factors, and prognosis in COPD Year: 2016 Distribution and significance of GOLD 2011 disease severity classification in patients with COPD in China: A national cross-sectional survey Source: Annual Congress 2013 –COPD: acute exacerbations and others Year: 2013 Characteristics of COPD in never smokers: results from the international burden of obstructive lung disease (BOLD) study Source: Annual Congress 2008 - Epidemiology of respiratory symptoms and COPD Year: 2008 Comorbidities and burden of COPD: A population based case-control study Source: Annual Congress 2013 –Comorbidities and respiratory disease and late-breaking abstracts Year: 2013 GOLD classifications and mortality in COPD: The HUNT study Source: Annual Congress 2013 –Investigating COPD in longitudinal studies Year: 2013 Comparison of characteristics of COPD patients with an established diagnosis, with those newly identified through case-finding – The Birmingham COPD cohort study Source: International Congress 2014 – Highlights in respiratory epidemiology Year: 2014 Measuring exacerbations in subjects with mild to moderate COPD from a population-based cohort: The CanCOLD study Source: Annual Congress 2013 –Factors associated with outcomes in COPD Year: 2013