Source: International Congress 2014 – Longitudinal studies of respiratory disease
Disease area: Paediatric lung diseases

Abstract

IntroductionWhilst it is increasingly accepted long term lung function outcomes may have their origins in early life, it is unclear what effect birth-weight has on later lung function in term-born children.Aims and objectivesWe determined how birth-weight effected lung function measurements in childhood and adolescence in term-born children.Methods Data for Caucasian, term-born, singleton, live births from the Avon Longitudinal Study of Parents and Children was used to determine the association between birth-weight and gestation and lung function at 8-9 (n=5320) and 14-17 (n=3474) years of age.ResultsAt age 8-9, standardised birth-weight (adjusted for age, height and gender) was significantly associated with lung function. This relationship was essentially unchanged when birth-weight was further adjusted for gestational age and for confounders. At age 14-17, the association between standardised birth-weight and spirometry measures remained significant for FVC and FEV₁ but were not for FEF_25-75. The estimated differences for FEV₁ were 31 and 43ml for a 1 Kg difference in birth-weight at 8-9 and 14-17 years of age respectively.ConclusionsBirth-weight had an effect on later respiratory outcomes in term-born children suggesting that interventions to achieve optimal birth-weight at term may prevent later deficits in lung function.

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S. Kotecha, W. J. Watkins, J. Henderson, S. Kotecha (Cardiff, Bristol, United Kingdom). The effect of birth-weight on longitudinal lung spirometry in school age children and adolescents born at term. Eur Respir J 2014; 44: Suppl. 58, 2977

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