Circulating C-reactive protein level is negatively correlated with lung volume
S. Kawase, S. Miyamoto, H. Ohnishi, T. Kubota, N. Ishikawa, Y. Haruta, N. Hattori, K. Yamane, N. Kohno, A. Yokoyama (Nankoku, Hiroshima, Japan)
Source: International Congress 2014 – Clinical management of interstitial lung diseases and vasculitis
Disease area: Airway diseases
Abstract Background: We previously reported that low lung volume is associated with an increased risk for prediabetes in healthy Japanese men. Systemic inflammation is a risk factor for diabetes, and is postulated to be associated with pulmonary dysfunction. However, its scientific information is limited.Aim: The aim of this study was to investigate the association between pulmonary function and systemic inflammation.Methods: This study included 1803 middle aged (40-60 years old) apparently healthy Japanese who had received regular health checkups. All subjects underwent chest radiogram, spirometry, and blood sampling. Subjects with abnormal pulmonary function (i.e. FEV1/FVC<70% or %predicted VC<80%) were excluded. To avoid the influences of smoking, current or former smokers were excluded. We reviewed their clinical data, and evaluated associations between pulmonary function and the other parameters.Results: The serum high sensitivity CRP (hsCRP) level positively correlated with body mass index (BMI), abdominal circumference (AC), triglyceride, LDL cholesterol, and HbA1c (p<0.01 for each). The serum hsCRP level did not correlate with FEV1/FVC (p=0.23), whereas it significantly negatively correlated with %predicted VC (p<0.01). In addition, a better association between hsCRP and %predicted VC was observed in male (r=-0.18, p<0.01) than in female (r=-0.09, p=0.055). Multivariate analyses demonstrated that %predicted VC, BMI, and AC were the independent determinants for hsCRP.Conclusions: Low lung volume is associated with serum CRP level. Although systemic inflammation could be induced by various factors, it might have a close relationship with subclinical pulmonary dysfunction.
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S. Kawase, S. Miyamoto, H. Ohnishi, T. Kubota, N. Ishikawa, Y. Haruta, N. Hattori, K. Yamane, N. Kohno, A. Yokoyama (Nankoku, Hiroshima, Japan). Circulating C-reactive protein level is negatively correlated with lung volume. Eur Respir J 2014; 44: Suppl. 58, 4517
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