The role of cardiac magnetic resonance in detection and monitoring of the treatment efficacy of heart involvement in EGPA patients
J. Fijolek, E. Wiatr, D. Gawryluk, U. Nowicka, J. Kober, D. Piotrowska-Kownacka, M. Szolkowska, K. Roszkowski-Sliz (Warsaw, Poland)
Source: International Congress 2014 – Clinical management of interstitial lung diseases and vasculitis
Disease area: Interstitial lung diseases
Abstract OBJECTIVE. The aim was to evaluate the ability of cardiac magnetic resonance (CMRI) to detection and monitoring of the treatment efficacy in eosinophilic granulomatosis with polyangiitis (EGPA) patients with cardiac involvement.METHODS. To the retrospective-prospective study were enrolled 33 cardiac involvement EGPA patients. In 19 of them CMRI at the moment of diagnosis was performed, in 14 – after 1-5 years after treatment, when CMRI was available. Patients were treated with corticosteroids (CSs) and/or cyclophosphamide (CY). The control CMRI one year after treatment was performed.RESULTS. All patients had heart injury in CMRI. Myocardial edema was present in 87,8% cases, 54,5% of patients had perfusion defects and in 94% - late gadolinium enhancement was observed. Among the 33 treated patients, control CMRI was performed in 28 cases. Improvement in CMRI (edema/perfusion defect decreased) was observed in 71,4% of patients – in 35% of them both lesions completely were replaced and in 10% of them all three lesions undergone completely remission. In 35,7% evolution to global fibrosis was found. In 28,5% of patients cardiac lesions were still active.CONCLUSION. CMRI is a sensitive, non-invasive method to detect cardiac lesions in EGPA patients. It helps to detect patients, who need combined therapy and helps evaluate the therapeutic effect.
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J. Fijolek, E. Wiatr, D. Gawryluk, U. Nowicka, J. Kober, D. Piotrowska-Kownacka, M. Szolkowska, K. Roszkowski-Sliz (Warsaw, Poland). The role of cardiac magnetic resonance in detection and monitoring of the treatment efficacy of heart involvement in EGPA patients. Eur Respir J 2014; 44: Suppl. 58, 4512
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