Source: International Congress 2014 – Clinical management of interstitial lung diseases and vasculitis
Disease area: Interstitial lung diseases

Abstract

INTRODUCTIONThe positive association between 18F-FDG PET/CT (PET/CT) and inflammatory biomarkers of sarcoidosis such as angiotensin converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) were already described but there is no data on relationship with chitotriosidase (CTO). The aim of our study was to test the correlation of PET/CT with CTO, sIL-2R, ACE.METHODSWe studied 24 sarcoidosis patients with symptoms of active lung sarcoidosis, who were not treated for sarcoidosis for at least three months. Patients underwent PET/CT (Siemens Biograph mCT). Simultaneously CTO (Perkin-Elmer fluorimeter), sIL-2R, ACE were obtained. Maximal standardized uptake value (SUVmax) was measured in thoracic lymph nodes (LN) and in pulmonary parenchyma (PP).RESULTSPET/CT detected inflammation in all patients. Mean value of SUVmax±SD at any location was 17.2±12.5, in LN 15.5±13.8 and in PP 5.9±6.8. There was significant positive relationship (1) of SUVmax at any location with sIL-2R (rho=0.49, p=0.03) and CTO (rho=0.54, p=0.007) but not ACE; (2) of SUVmax in LN with sIL-2R (rho=0.47, p=0.04) and CTO (rho=0.42, p=0.04), but not ACE; (3) and of SUVmax in PP with sIL-2R (rho=0.59, p=0.008) but not CTO nor ACE.CONCLUSIONThe results show for the first time positive correlation of SUVmax with sIL-2R and CTO at any location and in thoracic lymph nodes, while SUVmax in PP correlates only with sIL-2R. These findings could be accounted due to different sources of both biomarkers, since sIL-2R derives mainly from lymphocytes and CTO from macrophages. So both biomarkers could be used to detect active disease and thus reduce the number of radiologic examinations in sarcoidosis patient.

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N. Koren Pucelj, M. Harlander, M. Grmek, B. Salobir, M. Zupancic, M. Tercelj (Ljubljana, Slovenia). Correlation of 18F-FDG PET/CT with inflammatory biomarkers in sarcoidosis. Eur Respir J 2014; 44: Suppl. 58, 4503

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