Source: Annual Congress 2002 - Asthma and COPD: pharmacology
Disease area: Airway diseases

Abstract

From 73 patients with steriod-dependent bronchial asthma (women-52, men-21) at the age of 16 to 79, duration of disease from 2 to 34 years, 51 patients (70%) have treated by systemic corticosteroids more than 5 years (in most cases more than 10years), 6 - have treated during 3-5 years, 11 - 1-3 years, 5 - less than 1 year.
Most of the patients (62%) taking systemic steroids in dose 5-10mg/day of prednisolone, every third - 15-20 mg/day, 8% -25-30 mg/day. Despite of taking the high doses steroids (20-30 mg/day), 80% of the patients were using beta-2-adrenergic agonists about 8 times a day (from 4 to 10), also they were suffering from nocturnal symptoms every day and low FEV1 (from 27% to 78%). Only in every fifth case (14 patients) -FEV1 > 80%, asthmatic attacks <3 times a day, and 10 of them have taken systemic steroids less than 10mg/day.
Thus, constant treatment by systemic steroids don't ensure the control of bronchial asthma in corticosteroid-dependent patients.

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Citations should be made in the following way:
O. E. Bogooudinova, R. S. Fassakhov (Kazan, Russia). Corticosteroid-dependent bronchial asthma: lack of a control of disease. Eur Respir J 2002; 20: Suppl. 38, 754

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